NCT05206981

Brief Summary

This is a multi-center, observational patient registry. The primary objective of the study is to collect safety and performance data on the IlluminOss Device when used to provide stabilization and alignment for the treatment of traumatic or impending and pathologic fractures.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Jun 2021

Longer than P75 for all trials

Geographic Reach
2 countries

16 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress90%
Jun 2021Dec 2026

Study Start

First participant enrolled

June 11, 2021

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

January 8, 2022

Completed
17 days until next milestone

First Posted

Study publicly available on registry

January 25, 2022

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

April 17, 2026

Status Verified

April 1, 2026

Enrollment Period

5.5 years

First QC Date

January 8, 2022

Last Update Submit

April 14, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Composite Safety Success Rate

    12 Months

Secondary Outcomes (8)

  • Complications/Adverse Events

    12 Months

  • Successful Device Implantation

    12 Months

  • Fracture Healing

    12 Months

  • Disability & Return to Work Status

    12 Months

  • Discharge Status

    12 Months

  • +3 more secondary outcomes

Interventions

Patients may enroll in the registry if they have been implanted (retrospective) or will be implanted (prospective) with the IlluminOss device.

Eligibility Criteria

Age50 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The primary objective of the study is to collect safety and performance data on the IlluminOss Device when used to provide stabilization and alignment for the treatment of traumatic or impending and pathologic fractures. The device will be used in a manner consistent with the treating physician's regular clinical practice.

You may qualify if:

  • Patient has been deemed a candidate for the IlluminOss device
  • Patient is male or non-pregnant female
  • Patient is willing and able to comply with the postoperative scheduled clinical and radiographic evaluations
  • Patient is willing and able to give informed consent if required
  • Traumatic patient is over the age of 50
  • IlluminOss procedure is the initial procedure to treat the traumatic injury

You may not qualify if:

  • United States (U.S.)
  • This product is contraindicated in U.S. patients who have:
  • an active or incompletely treated infection that could involve the site where the device will be implanted;
  • are allergic to any of the implant materials or to dental glue;
  • have an intramedullary canal measuring smaller than the diameter of the delivery sheath provided at the site of the fracture;
  • distant foci of infections which may spread to the implant site, have open fractures with severe contamination;
  • or in patients for whom delivery sheath is unable to cross fracture site after proper fracture reduction and realignment.
  • European Union (EU)
  • This product is contraindicated in EU patients who have:
  • For all Bones:
  • Patients who are considered skeletally immature.
  • Presence of active or incompletely treated infections that could involve the site where the device will be implanted.
  • Patients allergic to any of the implant materials, or to dental glue.
  • Patients whose intramedullary canal at site of fracture measures smaller than the diameter of the sheath provided.
  • Uncooperative patient or patient with neurologic disorder, incapable of following directions.
  • +11 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (16)

Gulf Orthopedics

Mobile, Alabama, 36604, United States

COMPLETED

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

Presbyterian St Luke's Medical Ctr

Denver, Colorado, 80218, United States

RECRUITING

University of Miami Hospital

Miami, Florida, 33136, United States

RECRUITING

Weston Outpatient Surgical Center

Weston, Florida, 33326, United States

RECRUITING

Parkview Health

Fort Wayne, Indiana, 46845, United States

WITHDRAWN

Jacobi Medical Center

The Bronx, New York, 10461, United States

RECRUITING

Mission Hospital

Asheville, North Carolina, 28801, United States

WITHDRAWN

Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States

RECRUITING

Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States

RECRUITING

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States

RECRUITING

Ortho Rhode Island

Wakefield, Rhode Island, 02879, United States

RECRUITING

Memorial Hermann Hospital

Katy, Texas, 77494, United States

RECRUITING

St Vinzenz Hospital

Cologne, Germany

WITHDRAWN

Johannes Wesling Hospital Minden

Minden, Germany

COMPLETED

Petrus Hospital

Wuppertal, Germany

COMPLETED

MeSH Terms

Conditions

Fractures, Spontaneous

Condition Hierarchy (Ancestors)

Fractures, BoneWounds and Injuries

Central Study Contacts

Caitlin Smith, MPH

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Target Duration
1 Year
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 8, 2022

First Posted

January 25, 2022

Study Start

June 11, 2021

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

April 17, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations