Detection and Biopsy Guidance of Nasopharyngeal Carcinoma Based on Artificial Intelligence and Endoscopic Images
1 other identifier
observational
100
1 country
5
Brief Summary
Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for nasopharyngeal carcinoma identification during biopsy is low, thus leading to delayed or missed diagnosis for nasopharyngeal carcinoma upon initial attempt. Here, we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies and guide biopsy under endoscopic examination based on deep learning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2021
Typical duration for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2021
CompletedFirst Submitted
Initial submission to the registry
January 9, 2022
CompletedFirst Posted
Study publicly available on registry
January 21, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
June 28, 2025
CompletedOctober 17, 2023
October 1, 2023
1.9 years
January 9, 2022
October 13, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Aera under the receiver operating characteristic curve (AUC)
AUC of an deep learning-based model in discriminating nasopharyngeal carcinoma from bengin lesion.
three months
Secondary Outcomes (1)
Accuray
three months
Other Outcomes (1)
Statistical significance
Three years
Study Arms (5)
Sun Yat-Sen University Cancer Center
The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Sun Yat-Sen University Cancer Center. The physicians in Sun Yat-Sen University Cancer Center consider it necessary to perform an endoscopic image-guided biopsy.
Guangdong Provincial People's Hospital
The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Guangdong Provincial People's Hospital. The physicians in Guangdong Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy.
Nanfang Hospital, Southern Medical University
The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Nanfang Hospital. The physicians in Nanfang Hospital consider it necessary to perform an endoscopic image-guided biopsy.
Fujian Provincial Cancer Hospital
The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Fujian Provincial Cancer Hospital. The physicians in Fujian Provincial Cancer Hospital consider it necessary to perform an endoscopic image-guided biopsy.
Hainan Provincial People's Hospital
The participant who is found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy in Hainan Provincial People's Hospital. The physicians in Hainan Provincial People's Hospital consider it necessary to perform an endoscopic image-guided biopsy.
Interventions
For each participant presenting with a suspicious nasopharyngeal lesion, the attending physician will assess the lesion and determine the appropriate biopsy approach. The physician may decide on multiple biopsies from the lesion area, including one sample from within the lesion itself, another from 5-8 mm outside the lesion, and a third from 8-10 mm beyond the lesion. Alternatively, a single biopsy may be deemed sufficient based on the clinical judgment. Each of these specimens will undergo pathological examination to confirm whether they are carcinomatous or non-carcinomatous.
Eligibility Criteria
The patient was found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy and the clinican considered it necessary to perform an endoscopic image-guided biopsy.
You may qualify if:
- The patient was found to have a nasopharyngeal lesion through the nasopharyngeal endoscopy and the clinicans considered it necessary to perform an biopsy.
- Hemilateral lesion with limited size.
You may not qualify if:
- Patients with nasopharyngeal cancer, oropharyngeal cancer, hypopharyngeal cancer, etc. who have already been treated.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Chinese Academy of Scienceslead
- Sun Yat-sen Universitycollaborator
- Guangdong Provincial People's Hospitalcollaborator
- Nanfang Hospital, Southern Medical Universitycollaborator
- Fujian Cancer Hospitalcollaborator
- Hainan People's Hospitalcollaborator
Study Sites (5)
Fujian Provincial Cancer Hospital
Fuzhou, Fujian, 350014, China
Guangdong Provincial People's Hospital
Guangzhou, Guangdong, 510060, China
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, 510060, China
Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, 510060, China
Hainan Provincial People's Hospital
Haikou, Hainan, 570311, China
Related Publications (2)
Zwakenberg MA, Halmos GB, Wedman J, van der Laan BFAM, Plaat BEC. Evaluating Laryngopharyngeal Tumor Extension Using Narrow Band Imaging Versus Conventional White Light Imaging. Laryngoscope. 2021 Jul;131(7):E2222-E2231. doi: 10.1002/lary.29361. Epub 2021 Jan 4.
PMID: 33393666BACKGROUNDLi C, Jing B, Ke L, Li B, Xia W, He C, Qian C, Zhao C, Mai H, Chen M, Cao K, Mo H, Guo L, Chen Q, Tang L, Qiu W, Yu Y, Liang H, Huang X, Liu G, Li W, Wang L, Sun R, Zou X, Guo S, Huang P, Luo D, Qiu F, Wu Y, Hua Y, Liu K, Lv S, Miao J, Xiang Y, Sun Y, Guo X, Lv X. Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies. Cancer Commun (Lond). 2018 Sep 25;38(1):59. doi: 10.1186/s40880-018-0325-9.
PMID: 30253801RESULT
Biospecimen
For each participant exhibiting suspicious lesions during a nasopharyngeal endoscopy examination, the attending physician will determine the appropriate biopsy strategy based on the specific conditions of the lesion. The physician may opt for a single biopsy, taking a sample directly from within the lesion, or multiple biopsies, which would include one sample from inside the lesion, another from 5-8 mm outside the lesion, and a third from 8-10 mm outside the lesion. This decision will be grounded in clinical judgment and a comprehensive consideration of optimal diagnostic outcomes and patient safety.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
January 9, 2022
First Posted
January 21, 2022
Study Start
December 1, 2021
Primary Completion
October 30, 2023
Study Completion
June 28, 2025
Last Updated
October 17, 2023
Record last verified: 2023-10