Influence Factors of PD-1 Therapeutic Efficacy in Advanced Pancreatic Cancer

NCT05201729 | Unknown

• 1 other identifier: RJ2020368
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The early diagnosis rate of pancreatic cancer is low and most patients rely on palliative chemotherapy. However, the clinical benefit and objective response rate (ORR) of patients with first-line chemotherapy are low. Therefore,it is essential to develop new therapies to improve the survival of patients with pancreatic cancer.

Conditions

Pancreatic Ductal Adenocarcinoma, PDAC

Outcome Measures

Primary Outcomes (1)

• The difference of progression free survival (PFS)

  The time from random to the first occurrence of disease progression or death from any cause.

  1.5 years

Secondary Outcomes (2)

• Disease control rate (DCR)

  1.5 years

• the quality of participants'life

  1.5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with advanced pancreatic cancer who failed in the first-line chemotherapy

You may qualify if:

• Age \> 18 years old, male or female;
• Locally advanced or metastatic pancreatic ductal adenocarcinoma confirmed by histopathology / cytology of the primary and / or metastatic lesions and unsuitable for surgical resection;
• The failure of first-line chemotherapy with gemcitabine or FOLFINOX, disease progression or intolerable severe toxicity;
• The time from the end of the last chemotherapy should be more than 28 days;
• According to the evaluation criteria of solid tumor efficacy(RECIST 1.1), there should be at least one measurable lesion (non nodular lesion with the longest diameter of 210 mm, or nodular lesion with the shortest diameter of more than 15 mm);
• ECOG score:0\~2;
• Hematology, biochemistry and organ function indexes meet the following requirements:
• The absolute count of neutrophils (ANC) is more than 1.5x10% / L
• Platelet count (PLT) ≥ 80x109/l
• Hemoglobin (HB) ≥ 9.0 g/dl
• TBIL is less than 2.0 ULN, albumin (ALB) 230g / L
• In patients without liver metastasis, alanine transaminase (ALT) and / or aspartate -transaminase (AST) are less than 3.0 ULN
• Patients with liver metastasis, ALT and / or ASTS \<5.0\*ULN
• Serum creatinine (CREA) \< 1.5 x ULN, and creatinine clearance rate (CER) ≥ 30ml / min (Cockcroft-Gault);
• Women of childbearing age receives negative pregnancy test within 14 days before treatment. Male and female patients of childbearing age and their sexual partners agree to use reliable contraceptive methods within 14 days before enrollment, during the study and within 60 days after drug withdrawal；

You may not qualify if:

• If any of the following criteria is met, the patient should be excluded:
• Pancreatic ductal adenocarcinoma is diagnosed without histopathology / cytology;
• The target lesion has received local non-drug therapy (including radiotherapy, physical and / or chemical ablation, etc.), and there is no imaging progression;
• If the central nervous system metastasis is known, MRI should be performed to exclude it;
• Patients with carcinoma of Vater's ampulla or adenocarcinoma of biliary tract;
• Patients with partial or complete intestinal obstruction or complete biliary obstruction that cannot be relieved by active treatment;
• Ascites increases gradually after 2 weeks of conservative treatment (such as diuresis, sodium restriction, excluding ascites drainage);
• In the past 5 years, patients had a history of other malignant tumors, except for the following two cases: a)After other malignant tumors treated by a single operation, 5-year disease-free survival (DFS) was achieved;b)Cured basal cell carcinoma of the skin and cured carcinoma in situ of the cervix;
• Pregnant or lactating women;
• Active infection; Poorly controlled hypertension (≥ 150 / 100mmhg); Angina pectoris and unstable angina pectoris in recent 3 months, myocardial infarction, cardiac insufficiency (\> NYHA class II), schizophrenia, or history of psychotropic drug abuse in 1 year before enrollment;
• If HBV-DNA is more than 104 copies or more than 2000 IU / ml, antiviral and liver protection therapy should be carried out first. Only when HBV-DNA is less than 104 copies (2000 IU / ml), can the patients be enrolled in the group, and continue to take antiviral drugs, monitor liver function and HBV viral load; HCV antibody or HCV-RNA were positive; HIV infected patients (non high risk group, without clinical symptoms or signs indicating HIV infection, HIV test may not be carried out);
• Any of the following treatments were given within prior to enrollment:
• Within 4 weeks, received surgery of grade II or above (according to the operation classification catalogue (revised version in 2014) issued by the state health and Family Planning Commission); No matter whether it is related to tumor or not);
• Received extended radiotherapy within 4 weeks or limited range radiotherapy within 2 weeks (researchers in each center can judge the appropriate time to enter the group according to the recovery of toxicity after radiotherapy);
• Within 4 weeks or participating in other therapeutic / interventional clinical trials;

Sponsors & Collaborators

• Ruijin Hospital: lead

Study Sites (1)

Ruijin Hospital

Shanghai, Shanghai Municipality, 200433, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

n situ tissue samples of pancreatic cancer by EUS-FNAare immediately sent to the laboratory for sequencing. Serum, plasma and peripheral blood mononuclear cells (PBMC) are isolated from peripheral blood samples; Serum and plasma are stored in - 80 ℃ refrigerator, and PBMC are stored in liquid nitrogen. Biological samples of all patients are kept in a regulated biological sample bank.

MeSH Terms

Conditions

Anophthalmia with pulmonary hypoplasia

Study Officials

• Duowu Zou

  Ruijin Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yao Zhang

CONTACT

18019076695; zyrjxh97@sjtu.edu.cn

Duowu Zou

CONTACT

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: January 10, 2022
• First Posted: January 21, 2022
• Study Start: August 1, 2021
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: February 8, 2022

Record last verified: 2022-01

Locations

CN (1)