Creatine and Motor Skill Acquisition

NCT05201651 | Unknown Early Phase 1

• 1 other identifier: 2021-139
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators will conduct a double-blind, placebo-controlled, repeated measures study of the effects of oral creatine monohydrate supplementation on motor skill acquisition and neurophysiology in young healthy adults. After baseline testing, participants will be randomized to receive creatine supplementation or placebo for seven days. Participants will then complete three days of training on a motor skill task while consuming a maintenance dosage of creatine or placebo. TMS measures of neurophysiology will be assessed at baseline, and pre- and post-skill training on the first and third training days.

Conditions

Young Healthy Adults (no Medical Condition/Disease)

Keywords

motor learning; transcranial magnetic stimulation; motor cortex; corticospinal excitability; creatine

Outcome Measures

Primary Outcomes (1)

• Rate of change in movement time

  Both groups will perform a skill acquisition task that involves moving the dominant upper limb to direct a cursor towards moving targets presented on a computer screen. The task will be practiced over a period of three days. The time required to reach each moving target will be measured (i.e., movement time) with faster times indicating improved performance. The rate of improvement on the task over the three days will be determined.

  3 days

Secondary Outcomes (3)

• Single pulse motor evoked potential amplitude

  Days 1 and 3 of training

• Short-interval intracortical inhibition motor evoked potential amplitude

  Days 1 and 3 of training

• Intracortical facilitation motor evoked potential amplitude

  Days 1 and 3 of training

Study Arms (2)

Creatine

EXPERIMENTAL

Participants will orally consume creatine (20 grams in 4×5-gram servings for seven days), followed by 3-g/day during training days.

Dietary Supplement: Creatine Monohydrate

Placebo

PLACEBO COMPARATOR

Participants will orally consume maltodextrin placebo (20 grams in 4×5-gram servings for seven days), followed by 3-g/day during training days.

Dietary Supplement: Maltodextrin Placebo

Interventions

Creatine Monohydrate DIETARY_SUPPLEMENT

Participants will orally consume creatine (20 grams in 4×5-gram servings for seven days), followed by 3-g/day during training days. This 3-g/day dosage has been shown to maintain cellular creatine levels.

Creatine

Maltodextrin Placebo DIETARY_SUPPLEMENT

Participants will orally consume maltodextrin placebo (20 grams in 4×5-gram servings for seven days), followed by 3-g/day during training days.

Placebo

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• omnivore diet

You may not qualify if:

• pre-existing liver abnormalities
• pre-existing kidney abnormalities
• pre-existing neuromuscular abnormalities
• contraindications to transcranial magnetic stimulation
• consumption of dietary supplements containing creatine within 30 days prior to the start of the study

Sponsors & Collaborators

• University of Regina: lead

Study Sites (1)

University of Regina

Regina, Saskatchewan, S4S5N6, Canada

RECRUITING

MeSH Terms

Conditions

Disease

Interventions

Creatine

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Cameron S Mang, PhD

  University of Regina

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Cameron S Mang, PhD

CONTACT

3065854066; cameron.mang@uregina.ca

Darren G Candow, PhD

CONTACT

306-585-4906; darren.candow@uregina.ca

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Double blind. Individual without other involvement in study has study codes and prepares and distributes study kits containing creatine and placebo (similar appearance).
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants assigned to receive creatine supplementation or placebo.

Study Record Dates

• First Submitted: November 10, 2021
• First Posted: January 21, 2022
• Study Start: February 10, 2022
• Primary Completion: August 31, 2022
• Study Completion: August 31, 2022
• Last Updated: February 24, 2022

Record last verified: 2022-02

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)