AutoInflammatory Disease Alliance Registry (AIDA)

NCT05200715 | Recruiting

• 1 other identifier: AIDA V.04 19.05.2021
• Study Type: observational
• Target: 3,500
• Locations: 21 countries
• Sites: 111

Brief Summary

Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system. Among them, hereditary periodic syndromes, also known as monogenic AID, represent the prototype of this disease group, caused by mutations in genes involved in the regulation of innate immunity, inflammation and cell death. Based on recent experimental acquisitions in the field of monogenic AID, several immunologic disorders have been reclassified as polygenic/multifactorial AID, sharing pathogenetic and clinical features with hereditary periodic fevers. This has paved the way to new treatment targets for patients suffering from rare diseases of unknown origin, including Behçet's disease, Still disease, Schnitzler's disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, chronic recurrent multifocal osteomyelitis (CRMO), non-infectious uveitis and scleritis. Gathering information on such rare conditions is made difficult by the small number of patients, along with the difficulty of obtaining an accurate diagnosis in non-specialized clinical settings. In this context, the AIDA project promotes international collaboration among clinical centres to develop a permanent registry aimed at collecting demographic, genetic, clinical and therapeutic data of patients affected by monogenic and polygenic AID, in order to expand the current knowledge of these rare conditions.

Conditions

Hereditary Autoinflammatory Diseases; Schnitzler Syndrome; Behcet Syndrome; PFAPA Syndrome; Still Disease; Autoinflammatory Syndrome, Unspecified; Uveitis; Scleritis; Vexas Syndrome; Spondyloarthritis (SpA); Castleman Disease

Outcome Measures

Primary Outcomes (1)

• Change of the number of enrolled subjects

  This is an observational registry. The primary outcome is the increase of the number of subjects enrolled within each nosologic group.

  0-36-60-120 months

Secondary Outcomes (13)

• Change in the disease activity score

  0-36-60-120 months

• Change in the % of patients with new organ involvement

  0-36-60-120 months

• Incidence of death or adverse events

  0-36-60-120 months

• Change in the inflammatory markers values (ESR)

  0-36-60-120 months

• Change in the inflammatory markers values (CRP and SAA)

  0-36-60-120

Study Arms (1)

Patients affected by autoinflammatory diseases

Other: No intervention is foreseen by the protocol.

Interventions

No intervention is foreseen by the protocol. OTHER

Patients will be observed for 10 years at least. Demographic, genetic, clinical, clinimetric, laboratory, radiologic and therapeutic data will be collected both retrospectively and prospectively during routine follow-up visits.

Patients affected by autoinflammatory diseases

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients consecutively diagnosed and treated at the hospitals/ research centres affiliated to the AIDA Network (https://aidanetwork.org/en/)

You may qualify if:

• to be diagnosed with a monogenic AID according to the clinical phenotype and the detection of a confirmative genotype;
• to be diagnosed with clinical familial Mediterranean fever or Behçet's disease or Still disease or PFAPA syndrome or Schnitzler's disease or CRMO according to the corresponding clinical diagnostic and/or classification criteria;
• to be diagnosed with undifferentiated systemic AID;
• to be diagnosed with non-infectious uveitis according to the standardization for uveitis nomenclature (SUN) criteria;
• to be diagnosed with anterior or posterior non-infectious scleritis;
• to be diagnosed with spondyloarthritis according to ASAS and/or New York criteria;
• to be diagnosed with Castleman disease;

You may not qualify if:

• \- informed consent/assent not provided by the patient and/or his/her legal representative.

Sponsors & Collaborators

• University of Siena: lead

Study Sites (112)

University Algiers 1

Algiers, Algeria

RECRUITING

Université M'Hamed Bougara de Boumerdas

Boumerdas, Algeria

RECRUITING

Flinders University

Adelaide, Australia

RECRUITING

University of Adelaide

Adelaide, Australia

RECRUITING

Antwerp University Hospital

Antwerp, Belgium

RECRUITING

Hospital das Clinicas da Faculdade de Medicina HCFMUSP

São Paulo, Brazil

RECRUITING

Peking University People's Hospital

Beijing, China

RECRUITING

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

RECRUITING

Universidad del Rosario - Escuela de Medicina Y Ciencias de La Salud

Bogotá, Colombia

RECRUITING

Mansoura University, Faculty of Medicine

Al Mansurah, Egypt

RECRUITING

Al-Azhar University

Cairo, Egypt

RECRUITING

Cairo University

Cairo, Egypt

RECRUITING

Universitätsklinikum Schleswig-Holstein

Lübeck, Germany

RECRUITING

Evangelismos General Hospital

Athens, Greece

RECRUITING

National and Kapodistrian University of Athens

Athens, Greece

RECRUITING

National and Kapodistrian University of Athens

Athens, Greece

RECRUITING

Prabha Eye Clinic & Research Centre

Bangalore, India

RECRUITING

Postgraduate Institute of Medical Education and Research

Chandigarh, India

RECRUITING

Shariati Hospital - Tehran University of Medical Sciences

Tehran, Iran

RECRUITING

Azienda Ospedaliero-Universitaria Senese

Siena, Tuscany, 53100, Italy

RECRUITING

AOUC Policlinico di Bari

Bari, Italy

RECRUITING

University of Bari Medical School

Bari, Italy

RECRUITING

University-Hospital of Bari - UOC Medicina Interna

Bari, Italy

RECRUITING

University-Hospital of Bari - UOC Pediatria

Bari, Italy

RECRUITING

University-Hospital of Bari - UOC Reumatologia

Bari, Italy

RECRUITING

Central Hospital of Bolzano

Bolzano, Italy

RECRUITING

ASST degli Spedali Civili - P.O. Ospedale dei Bambini

Brescia, Italy

RECRUITING

ASST degli Spedali Civili

Brescia, Italy

RECRUITING

Azienda Ospedaliera Universitaria di Cagliari

Cagliari, Italy

RECRUITING

AOU Policlinico Vittorio Emanuele - Dip. Materno-Infantile

Catania, Italy

RECRUITING

ARNAS Garibaldi - Catania

Catania, Italy

RECRUITING

Azienda Ospedaliera di Catanzaro Pugliese Ciaccio

Catanzaro, Italy

RECRUITING

Ospedale SS Annunziata

Chieti, Italy

RECRUITING

Ospedale San Paolo

Civitavecchia, Italy

RECRUITING

Arcispedale Sant'Anna

Ferrara, Italy

RECRUITING

Azienda Ospedaliera Universitaria Careggi - SOD Medicina Interna Interdisciplinare

Florence, Italy

RECRUITING

Azienda Ospedaliero-Universitaria Careggi - SOD Immunologia e Terapie Cellulari

Florence, Italy

RECRUITING

Azienda Ospedaliero-Universitaria Meyer

Florence, Italy

RECRUITING

Azienza Ospedaliero-Universitaria Careggi - SOD Reumatologia

Florence, Italy

RECRUITING

Ospedale San Giovanni di Dio

Florence, Italy

RECRUITING

Sapienza University - Polo Pontino

Latina, Italy

RECRUITING

Ospedale Vito Fazzi

Lecce, Italy

RECRUITING

ASL1 Avezzano, Sulmona, L'Aquila

L’Aquila, Italy

RECRUITING

Università degli Studi di L'Aquila - UOC Medicina Interna e Nefrologia

L’Aquila, Italy

RECRUITING

AOU Policlinico G. Martino

Messina, Italy

RECRUITING

ASST Gaetano Pini/ CTO

Milan, Italy

RECRUITING

Policlinico di Milano

Milan, Italy

RECRUITING

ASST Fatebenefratelli Sacco - UO Medicina Generale

Milan, Italy

RECRUITING

ASST Fatebenefratelli Sacco - UOC Reumatologia

Milan, Italy

RECRUITING

ASST Gaetano Pini/CTO

Milan, Italy

RECRUITING

IRCCS Ospedale San Raffaele

Milan, Italy

RECRUITING

Ospedale Fatebenefratelli e Oftalmico

Milan, Italy

RECRUITING

Ospedale Fatebenefratelli e Oftalmico

Milan, Italy

RECRUITING

AORN Cardarelli

Napoli, Italy

RECRUITING

AOU Federico II

Napoli, Italy

RECRUITING

AOU Federico II

Napoli, Italy

RECRUITING

AOU Luigi Vanvitelli - UO Reumatologia

Napoli, Italy

RECRUITING

AOU Luigi Vanvitelli - UOC Pediatria 2

Napoli, Italy

RECRUITING

Azienda Ospedaliera Universitaria di Padova

Padua, Italy

RECRUITING

ARNAS Civico Di Cristina Benfratelli

Palermo, Italy

RECRUITING

ARNAS Ospedale Civico di Cristina Benfratelli

Palermo, Italy

RECRUITING

Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello

Palermo, Italy

RECRUITING

Università degli Studi di Palermo

Palermo, Italy

RECRUITING

Fondazione IRRCS San Matteo - SC Reumatologia

Pavia, Italy

RECRUITING

Azienda Ospedaliera di Perugia

Perugia, Italy

RECRUITING

Azienda Ospedaliero Universitaria Pisana

Pisa, Italy

RECRUITING

University of Pisa

Pisa, Italy

RECRUITING

AOU Policlinico Umberto I

Roma, Italy

RECRUITING

Azienda Ospedaliera San Camillo Forlanini

Roma, Italy

RECRUITING

IRCCS Fondazione PU Agostino Gemelli - UOC Medicina Interna Columbus

Roma, Italy

RECRUITING

IRCCS Fondazione PU Agostino Gemelli - UOC Pediatria

Roma, Italy

RECRUITING

Ospedale Pediatrico Bambino Gesù

Roma, Italy

RECRUITING

Ospedale Universitario Campus Bio-Medico

Roma, Italy

RECRUITING

Sapienza University - Polo Pontino

Roma, Italy

RECRUITING

Università di Roma Tor Vergata

Roma, Italy

RECRUITING

Azienda Ospedaliera Universitaria di Salerno

Salerno, Italy

RECRUITING

ATS Sardegna

Tempio Pausania, Italy

RECRUITING

AO Ordine Mauriziano

Torino, Italy

RECRUITING

A.S.L. Vercelli - Ospedale S. Andrea

Vercelli, Italy

RECRUITING

Azienda Ospedaliera Universitaria Integrata

Verona, Italy

RECRUITING

Tripoli Children Hospital

Tripoli, Libya

RECRUITING

Tripoli Children Hospital

Tripoli, Libya

RECRUITING

University Hospital of Martinique

Fort-de-France, Martinique

RECRUITING

Asociacion para Evitar la Ceguera en México

Mexico City, Mexico

RECRUITING

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, Mexico

RECRUITING

Medical University of Lodz

Lodz, Poland

RECRUITING

Central Clinical Hospital of the Ministry of National Defense - Military Institute of Medicine

Warsaw, Poland

RECRUITING

Sf. Maria Hospital - University of Medicine and Pharmacy "Carol Davila"

Bucharest, Romania

RECRUITING

Jazan University

Jizan, Saudi Arabia

RECRUITING

King Faisal Specialist Hospital and Research Center

Riyadh, Saudi Arabia

RECRUITING

King Saud University

Riyadh, Saudi Arabia

RECRUITING

Hospital Universitario Cruces - Instituto de investigación sanitaria Biocruces

Barakaldo, Spain

RECRUITING

Hospital Universitario Cruces

Barakaldo, Spain

RECRUITING

Hospital Clinic of Barcelona

Barcelona, Spain

RECRUITING

Hospital Fundación Jiménez Díaz

Madrid, Spain

RECRUITING

Hospital Ramón y Cajal

Madrid, Spain

RECRUITING

Hospital Universitario Fundación Jiménez Díaz/Hospital Universitario Rey Juan Carlos

Madrid, Spain

RECRUITING

Hospital Universitario Marqués de Valdecilla

Santander, Spain

RECRUITING

Hospital Universitari Doctor Peset

Valencia, Spain

RECRUITING

Farhat Hached Hospital

Sousse, Tunisia

RECRUITING

Çukurova University

Adana, Turkey (Türkiye)

RECRUITING

Ankara Yıldırım Beyazıt University

Ankara, Turkey (Türkiye)

RECRUITING

Gazi University

Ankara, Turkey (Türkiye)

RECRUITING

Hacettepe University Faculty of Medicine

Ankara, Turkey (Türkiye)

RECRUITING

Başakşehir Çam and Sakura City Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

Cerrahpasa Medical School Istanbul University

Istanbul, Turkey (Türkiye)

RECRUITING

Marmara University, Research And Education Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

Dokuz Eylul University School of Medicine

Izmir, Turkey (Türkiye)

RECRUITING

Manisa Celal Bayar University

Manisa, Turkey (Türkiye)

RECRUITING

Sakarya University

Sakarya, Turkey (Türkiye)

RECRUITING

Sivas Cumhuriyet University

Sivas, Turkey (Türkiye)

RECRUITING

I. Horbachevsky Ternopil National Medical University - Ternopil Regional Children's Hospital

Ternopil, Ukraine

RECRUITING

Related Publications (15)

• Gaggiano C, Vitale A, Obici L, Merlini G, Soriano A, Viapiana O, Cattalini M, Maggio MC, Lopalco G, Montin D, Jaber MA, Dagna L, Manna R, Insalaco A, Piga M, La Torre F, Berlengiero V, Gelardi V, Ciarcia L, Emmi G, Ruscitti P, Caso F, Cimaz R, Hernandez-Rodriguez J, Parronchi P, Sicignano LL, Verrecchia E, Iannone F, Sota J, Grosso S, Salvarani C, Frediani B, Giacomelli R, Mencarelli MA, Renieri A, Rigante D, Cantarini L. Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-alpha Receptor-Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA Network. Mediators Inflamm. 2020 Aug 7;2020:8562485. doi: 10.1155/2020/8562485. eCollection 2020.

  PMID: 32831641 BACKGROUND

• Vitale A, Sota J, Obici L, Ricco N, Maggio MC, Cattalini M, Ruscitti P, Caso F, Manna R, Viapiana O, Caggiano V, Emmi G, Insalaco A, Montin D, Licciardi F, Soriano A, Dagna L, Salvarani C, Lamacchia V, Hernandez-Rodriguez J, Giacomelli R, Frediani B, Renieri A, Cantarini L. Role of Colchicine Treatment in Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS): Real-Life Data from the AIDA Network. Mediators Inflamm. 2020 May 27;2020:1936960. doi: 10.1155/2020/1936960. eCollection 2020.

  PMID: 32565720 BACKGROUND

• Gaggiano C, Rigante D, Hernandez-Rodriguez J, Vitale A, Tarsia M, Soriano A, Lopalco G, Iannone F, Abdel Jaber M, Giacomelli R, Wiesik-Szewczyk E, Cattalini M, Frassi M, Piga M, Ragab G, Sota J, Zunica F, Floris A, Sabato V, Hegazy MT, Araujo O, Pelegrin L, Fabbiani A, Renieri A, Grosso S, Fabiani C, Frediani B, Cantarini L. Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: a multicenter observational study from the AIDA Network. Ther Adv Musculoskelet Dis. 2021 Sep 9;13:1759720X211037178. doi: 10.1177/1759720X211037178. eCollection 2021.

  PMID: 34527082 BACKGROUND

• Sota J, Rigante D, Cimaz R, Cattalini M, Frassi M, Manna R, Sicignano LL, Verrecchia E, Aragona E, Maggio MC, Lopalco G, Emmi G, Parronchi P, Cauli A, Wiesik-Szewczyk E, Hernandez-Rodriguez J, Gaggiano C, Tarsia M, Mourabi M, Ragab G, Vitale A, Fabiani C, Frediani B, Lamacchia V, Renieri A, Cantarini L; Autoinflammatory Diseases Alliance (AIDA) and the Autoinflammatory Diseases Working Group of the Italian Society of Rheumatology (SIR). Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry. Rheumatology (Oxford). 2021 Dec 1;60(12):5705-5712. doi: 10.1093/rheumatology/keab419.

  PMID: 33961014 BACKGROUND

• Sota J, Rigante D, Lopalco G, Emmi G, Gentileschi S, Gaggiano C, Ciarcia L, Berlengiero V, Mourabi M, Ricco N, Barneschi S, Mattioli I, Tosi GM, Frediani B, Tarsia M, di Scala G, Vitale A, Iannone F, Fabiani C, Cantarini L. Clinical profile and evolution of patients with juvenile-onset Behcet's syndrome over a 25-year period: insights from the AIDA network. Intern Emerg Med. 2021 Nov;16(8):2163-2171. doi: 10.1007/s11739-021-02725-9. Epub 2021 Apr 9.

  PMID: 33835406 BACKGROUND

• Vitale A, Obici L, Cattalini M, Lopalco G, Merlini G, Ricco N, Soriano A, La Torre F, Verrecchia E, Insalaco A, Dagna L, Jaber MA, Montin D, Emmi G, Ciarcia L, Barneschi S, Parronchi P, Ruscitti P, Maggio MC, Viapiana O, Sota J, Gaggiano C, Giacomelli R, Sicignano LL, Manna R, Renieri A, Lo Rizzo C, Frediani B, Rigante D, Cantarini L. Biotechnological Agents for Patients With Tumor Necrosis Factor Receptor Associated Periodic Syndrome-Therapeutic Outcome and Predictors of Response: Real-Life Data From the AIDA Network. Front Med (Lausanne). 2021 Jul 8;8:668173. doi: 10.3389/fmed.2021.668173. eCollection 2021.

  PMID: 34307404 BACKGROUND

• Tarsia M, Vitale A, Gaggiano C, Sota J, Maselli A, Bellantonio C, Guerriero S, Dammacco R, La Torre F, Ragab G, Hegazy MT, Fonollosa A, Paroli MP, Del Giudice E, Maggio MC, Cattalini M, Fotis L, Conti G, Mauro A, Civino A, Diomeda F, de-la-Torre A, Cifuentes-Gonzalez C, Tharwat S, Hernandez-Rodriguez J, Gomez-Caverzaschi V, Pelegrin L, Babu K, Gupta V, Minoia F, Ruscitti P, Costi S, Breda L, La Bella S, Conforti A, Mazzei MA, Carreno E, Amin RH, Grosso S, Frediani B, Tosi GM, Balistreri A, Cantarini L, Fabiani C. Effectiveness and Safety of Biosimilars in Pediatric Non-infectious Uveitis: Real-Life Data from the International AIDA Network Uveitis Registry. Ophthalmol Ther. 2024 Mar;13(3):761-774. doi: 10.1007/s40123-023-00863-1. Epub 2024 Jan 11.

  PMID: 38206518 DERIVED

• Ruscitti P, Sota J, Vitale A, Lopalco G, Iannone F, Morrone M, Giardini HAM, D'Agostin MA, Antonelli IPB, Almaghlouth I, Asfina KN, Khalil N, Sfikakis PP, Laskari K, Tektonidou M, Ciccia F, Iacono D, Riccio F, Ragab G, Hussein MA, Govoni M, Ruffilli F, Direskeneli H, Alibaz-Oner F, Giacomelli R, Navarini L, Bartoloni E, Riccucci I, Martin-Nares E, Torres-Ruiz J, Cipriani P, Di Cola I, Hernandez-Rodriguez J, Gomez-Caverzaschi V, Dagna L, Tomelleri A, Makowska J, Brzezinska O, Iagnocco A, Bellis E, Caggiano V, Gaggiano C, Tarsia M, Mormile I, Emmi G, Sfriso P, Monti S, Erten S, Del Giudice E, Lubrano R, Conti G, Olivieri AN, Lo Gullo A, Tharwat S, Karamanakos A, Gidaro A, Maggio MC, La Torre F, Cardinale F, Ogunjimi B, Maier A, Sebastiani GD, Opris-Belinski D, Frassi M, Viapiana O, Bizzi E, Carubbi F, Fotis L, Tufan A, Kardas RC, Wiesik-Szewczyk E, Jahnz-Rozyk K, Fabiani C, Frediani B, Balistreri A, Rigante D, Cantarini L. The administration of methotrexate in patients with Still's disease, "real-life" findings from AIDA Network Still Disease Registry. Semin Arthritis Rheum. 2023 Oct;62:152244. doi: 10.1016/j.semarthrit.2023.152244. Epub 2023 Jul 21.

  PMID: 37517110 DERIVED

• Gaggiano C, Maselli A, Sfikakis PP, Laskari K, Ragab G, Hegazy MT, Laymouna AH, Lopalco G, Almaghlouth IA, Asfina KN, Alahmed O, Giardini Mayrink HA, Parente de Brito Antonelli I, Cattalini M, Piga M, Sota J, Gentileschi S, Maggio MC, Opris-Belinski D, Hatemi G, Insalaco A, Olivieri AN, Tufan A, Karadeniz H, Kardas RC, La Torre F, Cardinale F, Marino A, Guerriero S, Ruscitti P, Tarsia M, Vitale A, Caggiano V, Telesca S, Iannone F, Parretti V, Frassi M, Aragona E, Ciccia F, Wiesik-Szewczyk E, Ionescu R, Sahin A, Akkoc N, Hinojosa-Azaola A, Tharwat S, Hernandez-Rodriguez J, Espinosa G, Conti G, Del Giudice E, Govoni M, Emmi G, Fabiani C, Balistreri A, Frediani B, Rigante D, Cantarini L; AIDA Network. Musculoskeletal manifestations in children with Behcet's syndrome: data from the AIDA Network Behcet's Syndrome Registry. Intern Emerg Med. 2023 Apr;18(3):743-754. doi: 10.1007/s11739-023-03215-w. Epub 2023 Mar 7.

  PMID: 36881285 DERIVED

• Gaggiano C, Vitale A, Tufan A, Ragab G, Aragona E, Wiesik-Szewczyk E, Ait-Idir D, Conti G, Iezzi L, Maggio MC, Cattalini M, Torre F, Lopalco G, Verrecchia E, de Paulis A, Sahin A, Insalaco A, Sfikakis PP, Marino A, Frassi M, Ogunjimi B, Opris-Belinski D, Parronchi P, Emmi G, Shahram F, Ciccia F, Piga M, Hernandez-Rodriguez J, Pereira RMR, Alessio M, Naddei R, Olivieri AN, Giudice ED, Sfriso P, Ruscitti P, Gobbi FL, Kucuk H, Sota J, Hussein MA, Malizia G, Jahnz-Rozyk K, Sari-Hamidou R, Romeo M, Ricci F, Cardinale F, Iannone F, Casa FD, Natale MF, Laskari K, Giani T, Franceschini F, Sabato V, Yildirim D, Caggiano V, Hegazy MT, Marzo RD, Kucharczyk A, Khellaf G, Tarsia M, Almaghlouth IA, Laymouna AH, Mastrorilli V, Dotta L, Benacquista L, Grosso S, Crisafulli F, Parretti V, Giordano HF, Mahmoud AAA, Nuzzolese R, Musso M, Chighizola CB, Gentileschi S, Morrone M, Cola ID, Spedicato V, Giardini HAM, Vasi I, Renieri A, Fabbiani A, Mencarelli MA, Frediani B, Balistreri A, Tosi GM, Fabiani C, Lidar M, Rigante D, Cantarini L. The Autoinflammatory Diseases Alliance Registry of monogenic autoinflammatory diseases. Front Med (Lausanne). 2022 Sep 9;9:980679. doi: 10.3389/fmed.2022.980679. eCollection 2022.

  PMID: 36160138 DERIVED

• Della Casa F, Vitale A, Cattalini M, La Torre F, Capozio G, Del Giudice E, Maggio MC, Conti G, Alessio M, Ogunjimi B, Ragab G, Emmi G, Aragona E, Giani T, Lopalco G, Parronchi P, Shahram F, Verrecchia E, Ricci F, Cardinale F, Di Noi S, Nuzzolese R, Lubrano R, Patroniti S, Naddei R, Sabato V, Hussein MA, Dotta L, Mastrorilli V, Gentileschi S, Tufan A, Caggiano V, Hegazy MT, Sota J, Almaghlouth IA, Ibrahim A, Wiesik-Szewczyk E, Ozkiziltas B, Grosso S, Frassi M, Tarsia M, Pereira RMR, Taymour M, Gaggiano C, Colella S, Fabiani C, Morrone M, Ruscitti P, Frediani B, Spedicato V, Giardini HAM, Balistreri A, Rigante D, Cantarini L. Development and implementation of the AIDA International Registry for patients with Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis syndrome. Front Pediatr. 2022 Jul 22;10:930305. doi: 10.3389/fped.2022.930305. eCollection 2022.

  PMID: 35935379 DERIVED

• Vitale A, Caggiano V, Della Casa F, Hernandez-Rodriguez J, Frassi M, Monti S, Tufan A, Telesca S, Conticini E, Ragab G, Lopalco G, Almaghlouth I, Pereira RMR, Yildirim D, Cattalini M, Marino A, Giani T, La Torre F, Ruscitti P, Aragona E, Wiesik-Szewczyk E, Del Giudice E, Sfikakis PP, Govoni M, Emmi G, Maggio MC, Giacomelli R, Ciccia F, Conti G, Ait-Idir D, Lomater C, Sabato V, Piga M, Sahin A, Opris-Belinski D, Ionescu R, Bartoloni E, Franceschini F, Parronchi P, de Paulis A, Espinosa G, Maier A, Sebastiani GD, Insalaco A, Shahram F, Sfriso P, Minoia F, Alessio M, Makowska J, Hatemi G, Akkoc N, Li Gobbi F, Gidaro A, Olivieri AN, Al-Mayouf SM, Erten S, Gentileschi S, Vasi I, Tarsia M, Mahmoud AAA, Frediani B, Fares Alzahrani M, Laymouna AH, Ricci F, Cardinale F, Jahnz-Rozyk K, Tosi GM, Crisafulli F, Balistreri A, Dagostin MA, Ghanema M, Gaggiano C, Sota J, Di Cola I, Fabiani C, Giardini HAM, Renieri A, Fabbiani A, Carrer A, Bocchia M, Caroni F, Rigante D, Cantarini L. Development and Implementation of the AIDA International Registry for Patients With VEXAS Syndrome. Front Med (Lausanne). 2022 Jul 11;9:926500. doi: 10.3389/fmed.2022.926500. eCollection 2022.

  PMID: 35899212 DERIVED

• Vitale A, Della Casa F, Ragab G, Almaghlouth IA, Lopalco G, Pereira RM, Guerriero S, Govoni M, Sfikakis PP, Giacomelli R, Ciccia F, Monti S, Ruscitti P, Piga M, Lomater C, Tufan A, Opris-Belinski D, Emmi G, Hernandez-Rodriguez J, Sahin A, Sebastiani GD, Bartoloni E, Akkoc N, Gunduz OS, Cattalini M, Conti G, Hatemi G, Maier A, Parronchi P, Del Giudice E, Erten S, Insalaco A, Li Gobbi F, Maggio MC, Shahram F, Caggiano V, Hegazy MT, Asfina KN, Morrone M, Prado LL, Dammacco R, Ruffilli F, Arida A, Navarini L, Pantano I, Cavagna L, Conforti A, Cauli A, Marucco EM, Kucuk H, Ionescu R, Mattioli I, Espinosa G, Araujo O, Karkas B, Canofari C, Sota J, Laymouna AH, Bedaiwi AA, Colella S, Giardini HAM, Albano V, Lo Monaco A, Fragoulis GE, Kardas RC, Berlengiero V, Hussein MA, Ricci F, La Torre F, Rigante D, Wiesik-Szewczyk E, Frassi M, Gentileschi S, Tosi GM, Dagostin MA, Mahmoud AAA, Tarsia M, Alessio G, Cimaz R, Giani T, Gaggiano C, Iannone F, Cipriani P, Mourabi M, Spedicato V, Barneschi S, Aragona E, Balistreri A, Frediani B, Fabiani C, Cantarini L; Autoinflammatory Diseases Alliance (AIDA) Network. Development and implementation of the AIDA International Registry for patients with Behcet's disease. Intern Emerg Med. 2022 Oct;17(7):1977-1986. doi: 10.1007/s11739-022-03038-1. Epub 2022 Jul 14.

  PMID: 35831701 DERIVED

• Della Casa F, Vitale A, Lopalco G, Ruscitti P, Ciccia F, Emmi G, Cattalini M, Wiesik-Szewczyk E, Maggio MC, Ogunjimi B, Sfikakis PP, Tufan A, Al-Mayouf SM, Del Giudice E, Aragona E, La Torre F, Sota J, Colella S, Di Cola I, Iacono D, Mattioli I, Jahnz-Rozyk K, Joos R, Laskari K, Gaggiano C, Abbruzzese A, Cipriani P, Rozza G, AlSaleem A, Yildirim D, Tarsia M, Ragab G, Ricci F, Cardinale F, Korzeniowska M, Frassi M, Caggiano V, Saad MA, Pereira RM, Berlengiero V, Gentileschi S, Guerriero S, Giani T, Gelardi V, Iannone F, Giardini HAM, Almaghlouth IA, Kardas RC, Ait-Idir D, Frediani B, Balistreri A, Fabiani C, Rigante D, Cantarini L. Development and Implementation of the AIDA International Registry for Patients With Undifferentiated Systemic AutoInflammatory Diseases. Front Med (Lausanne). 2022 Jun 10;9:908501. doi: 10.3389/fmed.2022.908501. eCollection 2022.

  PMID: 35755024 DERIVED

• Vitale A, Della Casa F, Lopalco G, Pereira RM, Ruscitti P, Giacomelli R, Ragab G, La Torre F, Bartoloni E, Del Giudice E, Lomater C, Emmi G, Govoni M, Maggio MC, Maier A, Makowska J, Ogunjimi B, Sfikakis PP, Sfriso P, Gaggiano C, Iannone F, Dagostin MA, Di Cola I, Navarini L, Ahmed Mahmoud AA, Cardinale F, Riccucci I, Paroli MP, Marucco EM, Mattioli I, Sota J, Abbruzzese A, Antonelli IPB, Cipriani P, Tufan A, Fabiani C, Ramadan MM, Cattalini M, Kardas RC, Sebastiani GD, Giardini HAM, Hernandez-Rodriguez J, Mastrorilli V, Wiesik-Szewczyk E, Frassi M, Caggiano V, Telesca S, Giordano HF, Guadalupi E, Giani T, Renieri A, Colella S, Cataldi G, Gentile M, Fabbiani A, Al-Maghlouth IA, Frediani B, Balistreri A, Rigante D, Cantarini L. Development and Implementation of the AIDA International Registry for Patients With Still's Disease. Front Med (Lausanne). 2022 Apr 7;9:878797. doi: 10.3389/fmed.2022.878797. eCollection 2022.

  PMID: 35463015 DERIVED

Related Links

• Website of the AIDA Network

MeSH Terms

Conditions

Hereditary Autoinflammatory Diseases; Schnitzler Syndrome; Behcet Syndrome; Marshall syndrome; Arthritis, Juvenile; Uveitis; Scleritis; VEXAS syndrome; Spondylarthritis; Castleman Disease

Condition Hierarchy (Ancestors)

Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Skin Diseases; Skin and Connective Tissue Diseases; Monoclonal Gammopathy of Undetermined Significance; Paraproteinemias; Immunoproliferative Disorders; Immune System Diseases; Mouth Diseases; Stomatognathic Diseases; Uveitis, Anterior; Panuveitis; Uveal Diseases; Eye Diseases; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Skin Diseases, Vascular; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Autoimmune Diseases; Scleral Diseases; Spondylitis; Spinal Diseases; Bone Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases

Central Study Contacts

Luca Cantarini, MD,PhD

CONTACT

+393479385457; cantarini@unisi.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Professor of Rheumatology

Study Record Dates

• First Submitted: December 18, 2021
• First Posted: January 21, 2022
• Study Start: August 6, 2020
• Primary Completion (Estimated): August 6, 2026
• Study Completion (Estimated): August 6, 2030
• Last Updated: July 10, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CO (1); ME (2); SA (3); BR (1); AL (2); GR (3); IT (61); UA (1); CN (2); MA (1); IR (1); TU (11); EG (3); IN (2); BE (1); LI (2); AU (2); PL (2); RO (1); ES (8); DE (1)