Optic Nerve Diameter and Intraocular Pressure Changes in Patients Undergoing Vitrectomy Under General Anesthesia
Intraoperative Optic Nerve Diameter and Intraocular Pressure Changes in Patients Undergoing Vitrectomy (PPV) Surgery Under General Anesthesia and Their Effects on Vision in the Postoperative Period
1 other identifier
observational
60
1 country
2
Brief Summary
This study aimed to measure optic nerve sheath changes in the intraoperative period in patients who underwent vitrectomy surgery and to investigate the intraoperative factors that may affect this. Standard anesthesia protocol will be applied to all patients participating in the study. Optic nerve sheath diameter measurements of the patients taken to the operating room will be made on the operating table by ultrasonography method. Standard anesthesia induction will be performed following SpO2 and ECG monitoring in routine anesthesia monitoring. Depth of anesthesia will be evaluated with routine hemodynamic data.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2022
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2022
CompletedFirst Submitted
Initial submission to the registry
January 7, 2022
CompletedFirst Posted
Study publicly available on registry
January 19, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2024
CompletedJanuary 13, 2023
January 1, 2023
2.5 years
January 7, 2022
January 12, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Optic Nerve Diameter
This study aims to use the anesthesia methods routinely applied in our hospital's vitrectomy operations. With general anesthesia, intracranial pressure changes, an indication of which is an increase in the diameter of the optic nerve sheath. The expected benefit of this study is to reveal the effects of general anesthesia, patient profile (age, comorbidity, BMI), ventilator parameters on optic nerve sheath diameter in patients undergoing vitrectomy surgery, and to provide optimal intraoperative conditions in the surgery of these patients with parameters that can be corrected and to improve their vision in the postoperative period. The optic nerve diameter will be measured at determined time intervals, and changes in diameter will be noted in the study.
one month
Secondary Outcomes (1)
Vision field
one month
Study Arms (3)
Group with local anesthesia
The group that did not apply general anesthesia
Group with Sevoflurane
The Sevoflurane used for maintenance of general anesthesia
Group with Propofol
The Propofol (IV) used for maintenance of general anesthesia
Interventions
Optic Nerve Diameter will be measured in the intraoperative period and postoperative 1st month by ultrasonography method.
Eligibility Criteria
patients undergoing vitrectomy surgery
You may qualify if:
- Being over 18 years old
- Taken to elective vitrectomy surgery
- Asa I - II - III patients
- GKS 15
You may not qualify if:
- Emergency surgeries
- Patients with a GCS of less than 15 or whose cognitive functions have not been evaluated as clinically sufficient.
- In cases that cause the termination of the surgical procedure for any reason during the operation
- Patients followed by neurosurgery and patients with intracranial events
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Akdeniz University Medical Faculty Department of Anesthesiology and Reanimation
Antalya, 07059, Turkey (Türkiye)
Akdeniz University Hospital
Antalya, 07070, Turkey (Türkiye)
Related Publications (4)
Chen LM, Wang LJ, Hu Y, Jiang XH, Wang YZ, Xing YQ. Ultrasonic measurement of optic nerve sheath diameter: a non-invasive surrogate approach for dynamic, real-time evaluation of intracranial pressure. Br J Ophthalmol. 2019 Apr;103(4):437-441. doi: 10.1136/bjophthalmol-2018-312934. Epub 2018 Oct 25.
PMID: 30361274BACKGROUNDRobba C, Santori G, Czosnyka M, Corradi F, Bragazzi N, Padayachy L, Taccone FS, Citerio G. Optic nerve sheath diameter measured sonographically as non-invasive estimator of intracranial pressure: a systematic review and meta-analysis. Intensive Care Med. 2018 Aug;44(8):1284-1294. doi: 10.1007/s00134-018-5305-7. Epub 2018 Jul 17.
PMID: 30019201BACKGROUNDBlair K, Czyz CN. Retinal Detachment. 2024 Feb 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK551502/
PMID: 31855346BACKGROUNDIllarionov AM. [The blood coagulation and its fibrinolytic activity in patients who have sustained an apoplectic stroke]. Sov Med. 1966 Feb;29(2):76-7. No abstract available. Russian.
PMID: 6011519BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, MD
Study Record Dates
First Submitted
January 7, 2022
First Posted
January 19, 2022
Study Start
January 1, 2022
Primary Completion
July 1, 2024
Study Completion
September 1, 2024
Last Updated
January 13, 2023
Record last verified: 2023-01