Diaphragmatic Thickness and Pulmonary Function in Parkinson's Disease

NCT05194748 | Completed

• 1 other identifier: AIBU-FTR-ETB-002
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

Ultrasound can give important information about the morphology of the diaphragm and the amount of contraction. Our aim, with the prediction that a restrictive pathology will occur in the pulmonary function with the addition of camptocormia in Parkinson's patients; to compare respiratory functions in Parkinson's patients with and without camptocormia, to investigate the correlation between ultrasonographically measured diaphragmatic thickness and pulmonary function test values.

Conditions

Parkinson's Disease and Parkinsonism

Outcome Measures

Primary Outcomes (2)

• Pulmonary function test

  When the patient is in the suIt will be evaluated by conventional spirometric measurements. Pulmonary function tests will be applied to all individuals in a sitting position with the "Vmax Encore PFT system, Carefusion, CA USA" brand test device. In each measurement, the maneuvers will be repeated at least 3 times and the best values will be recorded. Forced vital capacity (FVC), expire in the first second of forced expiration (FEV1), and the ratio of FEV1 to FVC (FEV1/FVC) will be recorded.pine position, by placing a transducer on the chest wall at the level of the right 9th intercostal space, diaphragmatic movement will be monitored during inspiration, and diaphragmatic thickness will be measured at the end of expiration and inspiration. Thrombus location was evaluated proximal and/or distally by performing Doppler ultrasound

  1 hour

• Ultrasonography

  When the patient is in the supine position, by placing a transducer on the chest wall at the level of the right 9th intercostal space, diaphragmatic movement will be monitored during inspiration, and diaphragmatic thickness will be measured at the end of expiration and inspiration. Thrombus location was evaluated proximal and/or distally by performing Doppler ultrasound

  1 hour

Secondary Outcomes (1)

• Camptocormia measurement

  1 hour

Study Arms (2)

camptocormia group

Diaphragmatic thickness will be measured by ultrasonography. Respiratory function will be evaluated by spirometric measurements. Postural deviations of the spine, knees, and hips will be recorded through photographs taken from the side and back

Other: No intervention, observational only

no camptocormia group

Diaphragmatic thickness will be measured by ultrasonography. Respiratory function will be evaluated by spirometric measurements. Postural deviations of the spine, knees, and hips will be recorded through photographs taken from the side and back

Other: No intervention, observational only

Interventions

No intervention, observational only OTHER

No intervention, observational only

camptocormia group; no camptocormia group

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals diagnosed with Parkinson's Disease in our clinic between June 2021 and January 2023.

You may qualify if:

• Being diagnosed with Parkinson's
• Volunteer to participate in the study

You may not qualify if:

• Being in contact with or suffering from COVID-19
• Having diseases that increase intra-abdominal pressure and venous insufficiency
• Having diseases that affect diaphragmatic motility
• Have had recent thoracic or abdominal surgery
• Having a parenchymal, pleural, or chest wall mass that may cause restriction on a recent chest X-ray or CT

Sponsors & Collaborators

• Abant Izzet Baysal University: lead

Study Sites (1)

Abant Izzet Baysal University Faculty of Health Science

Bolu, 14100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease; Parkinsonian Disorders

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Ramazan Kurul, Ph.D

  Abant Izzet Baysal University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: January 4, 2022
• First Posted: January 18, 2022
• Study Start: December 24, 2021
• Primary Completion: January 1, 2023
• Study Completion: February 15, 2023
• Last Updated: April 26, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)