MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD

NCT05194254 | Recruiting

• 1 other identifier: PI2021_843_0194
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an essential step in achieving joint attention. The originality of this study is to improve the design of visual percepts (in the form of video) in order to mimic an ecological environment as much as possible by using MRI-ET coupling. The second originality of this study is the longitudinal exploration of the neurodevelopment of social cognition in autistic children. Studies by the Redcay and Oberwelland teams observe different activations at different ages. The hypothesis is that the perception of joint attention varies over time in people with ASD. To date, there are no studies to determine the influence of childhood neurodevelopment in autistic people on the perception of joint attention. It would be unprecedented to use the MRI-ET pairing as a tool for assessing social cognition as a function of the development of children with ASD.

Conditions

ASD; Functional Magnetic Resonance Imaging; Eye Tracking; Social Cognition; Joint Attention

Keywords

ASD; Functional magnetic resonance imaging; Eye Tracking; social cognition; joint attention

Outcome Measures

Primary Outcomes (1)

• difference of mapping IRM-ET results between both patient groups

  both patient groups are : the group of people with Autism Spectrum Disorders and Typical Development group of people

  one day

Study Arms (2)

ASD

EXPERIMENTAL

people with Autism Spectrum Disorders

Other: MRI-ET

TD

ACTIVE COMPARATOR

Typical Development) group of people

Other: MRI-ET

Interventions

MRI-ET OTHER

coupled fMRI and Eye Tracking tools

ASD; TD

Eligibility Criteria

• Age: 10 Years - 20 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• For the group of people with Autism Spectrum Disorders (experimental group):
• Age between 10 to 20 years old
• IQ test evaluation (regardless of the result) performed by a trained psychologist
• Obtaining informed oral and written consent after appropriate information
• Obtaining informed oral and written consent from the legal guardian after information
• Be affiliated with social security
• No contraindication to magnetic resonance imaging
• For the TD (Typical Development) group of people (control group):
• Age between 10 to 20 years old
• IQ test evaluation (regardless of the result) performed by a trained psychologist
• Obtaining informed oral and written consent after appropriate information
• Obtaining informed oral and written consent from the legal guardian after information
• Be affiliated with social security
• No contraindication to magnetic resonance imaging

You may not qualify if:

• For all groups:
• Age outside the range 10 to 20 years
• Person with a contraindication to MRI (including claustrophobia, pace maker, neurosurgical clips, vascular clips, heart valves, ventriculoperitoneal valves, cochlear implant, neurostimulator, intraocular metal shards, joint prosthesis, etc.)
• Person suffering from major obesity (\> 140 kg) not allowing him to enter the tunnel of the MRI machine (diameter \<70cm)
• Pregnant or breastfeeding woman
• Person under guardianship or guardianship or deprived of liberty by a judicial or administrative decision
• For TD people (control group):
• Person with psychiatric disorders such as attention disorder with or without hyperactivity, depression, bipolar disorder and schizophrenia.
• Person with a neurological history such as epilepsy and / or neurovascular accident.

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, Picardie, 80054, France

RECRUITING

Central Study Contacts

Jean-Marc Constans, Pr

CONTACT

03 22 08 75 15; constans.jean-marc@chu-amiens.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 4, 2022
• First Posted: January 18, 2022
• Study Start: January 4, 2022
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: May 28, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)