Effect of Allopurinol on Left Ventricular Function in Children With Dilated Cardiomyopathy
1 other identifier
observational
100
0 countries
N/A
Brief Summary
The aim of this study is to detect effect of allopurinol supplementation in pediatric patients with dilated cardiomyopathy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2022
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 26, 2021
CompletedFirst Posted
Study publicly available on registry
January 18, 2022
CompletedStudy Start
First participant enrolled
May 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2023
CompletedJanuary 18, 2022
January 1, 2022
1 year
November 26, 2021
January 12, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
difference of echocardiography parameters and ejection fraction between DCM patients taking Allopurinol and patients not taking
follow up of improvement of ejection fraction by echocardiography
6 months
Study Arms (1)
Allopurinol
we plan to follow up effect of Allopurinol on left ventricular function in children with dilated cardiomyopathy for 6 months
Interventions
examined patients with dilated cardiomyopathy will receive allopurinol for 6 months
Eligibility Criteria
This study is a prospective cohort study, it will include 100 patient who attend pediatric cardiology unit or pediatric cardiology outpatient clinic in Assiut university children hospital in Assiut governate, Egypt
You may qualify if:
- children (1-16) year's age with impaired left ventricular systolic function due to dilated cardiomyopathy, who attend pediatric cardiology unit 2-children attend to pediatric cardiology out patient clinic in Assiut university children hospital 3-children with no allergic reaction from allopurinol
You may not qualify if:
- children with impaired left ventricular systolic function due to other causes like congenital heart diseases
- children with acquired heart diseases
- patients with allergic reaction or contra indicated from Allopurinol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB; American Heart Association; Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; Council on Epidemiology and Prevention. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006 Apr 11;113(14):1807-16. doi: 10.1161/CIRCULATIONAHA.106.174287. Epub 2006 Mar 27.
PMID: 16567565BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- principal investigator
Study Record Dates
First Submitted
November 26, 2021
First Posted
January 18, 2022
Study Start
May 1, 2022
Primary Completion
May 1, 2023
Study Completion
July 1, 2023
Last Updated
January 18, 2022
Record last verified: 2022-01