Correlation Between Elastic Modulus of Ultrasonic Shear Wave and Tumor Stromal Component in Pancreatic Cancer

NCT05187416 | Unknown

• 1 other identifier: KY20212175-C-1
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Pancreatic cancer is a gastrointestinal tumor with a high degree of malignancy. Currently, there are many first-line chemotherapy regimens in clinical practice, but the individual selection of chemotherapy regimens has not been unanimously recognized.This study is aimed at exploring the correlation between the two-dimensional shear wave elastography (2D - SWE) parameters and pancreatic cancer stromal elements proportion through an ultrasound scan for resectable pancreatic cancer cases and postoperative pathological specimen analysis. Then determine if the pancreatic cancer two-dimensional shear wave elastography can guide clinicians selecting chemotherapy scheme by predicting tumor stromal elements .These results are expected to provide an effective non-invasive diagnostic basis for individualized treatment of pancreatic cancer.

Conditions

Pancreatic Neoplasms

Keywords

2D-SWE

Outcome Measures

Primary Outcomes (1)

• Elastic modulus measured by Ultrasonic shear wave and tumor stromal component assessed by pathological analysis in pancreatic cancer

  Baseline (Preoperative ultrasound elastography examination)

Interventions

two-dimensional shear wave elastography DIAGNOSTIC_TEST

Preoperative ultrasound elastography examination

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive cases of pancreatic cancer in Xijing Hospital

You may qualify if:

• Patients with resectable pancreatic cancer underwent ultrasound examination before surgery
• Conventional ultrasound can clearly show pancreatic space-occupying lesions and the elastic measurements show good images
• The patient agrees to receive ultrasound elasticity examination and signs informed consent
• All patients had no history of radiotherapy or chemotherapy before ultrasound examination
• All clinical case data and auxiliary examination data are complete and accessible.

You may not qualify if:

• Ultrasound evaluation was not performed before ultrasound-guided needle biopsy
• Conventional ultrasound could not clearly show pancreatic space-occupying lesions or poor elastic measurement images
• Patients who refuse to accept examination or give up treatment
• Patients receiving neoadjuvant chemotherapy or radiotherapy before ultrasound examination
• Incomplete clinical data and auxiliary examination data.

Sponsors & Collaborators

• Xijing Hospital: lead

Study Sites (1)

Xijing Hospital

Xi'an, Shaanxi, 710032, China

RECRUITING

MeSH Terms

Conditions

Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Central Study Contacts

Kunlong Duan

CONTACT

+8617795629885; 804868814@qq.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 20, 2021
• First Posted: January 11, 2022
• Study Start: February 1, 2022
• Primary Completion: October 1, 2022
• Study Completion: October 1, 2022
• Last Updated: January 19, 2022

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)