Effects of Propofol-Induced Anaesthesia on the ST-segment of the ECG

NCT05185401 | Unknown

• 1 other identifier: Prop ST-Segment
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the effect of propofol induced general anaesthesia on the ST-segment of the electrocardiogram. This will be realised by retrospectively analysing the ECG-recordings from adult patients undergoing any treatment at the Catheterisation Laboratory. The ST-segment and other ECG measurements from induction of anaesthesia up to 20 minutes later, will be assessed and compared to the baseline values of the respective segments acquired before injecting propofol. It is essential in this study to exclude any patients burdened with the diagnosis, suspicion or family history of Brugada syndrome.

Conditions

No Specific Condition (Patients Without Brugada Syndrome)

Outcome Measures

Primary Outcomes (1)

• ST-segment variations after propofol administration.

  Determine ST-segment variations in mm (either augmentation or suppression) on the ECG in the 20 minute period after administration of propofol in comparison to the baseline ECG

  Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol

Secondary Outcomes (1)

• Additional ECG-segment variations after propofol administration

  Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol

Study Arms (1)

non-Brugada population

Adult patients who underwent general anaesthesia (with propofol as induction agent) at the catheterisation laboratory of the UZ Brussel

Other: Observational study

Interventions

Observational study OTHER

Retrospective data-analysis

non-Brugada population

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients who underwent a surgical procedure under propofol-based general anaesthesia in the CathLab of UZB.

You may qualify if:

• Induction of anaesthesia with propofol
• Monitored anaesthesia in the CathLab of the Universitair Ziekenhuis Brussel

You may not qualify if:

• Brugada Syndrome or family history of Brugada syndrome
• Paediatric population (age \<18)
• Patients who did not receive propofol during the procedure
• Patients who presented with fever (central core temperature \>38,0°C)

Sponsors & Collaborators

• Universitair Ziekenhuis Brussel: lead

Study Sites (1)

Universitair Ziekenhuis Brussel

Brussels, Brussels Capital, 1090, Belgium

Location

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 22, 2021
• First Posted: January 11, 2022
• Study Start: February 1, 2022
• Primary Completion: April 1, 2022
• Study Completion: April 1, 2022
• Last Updated: February 23, 2022

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)