Epidemiology of Pecan Nut Allergy

NCT05185362 | Unknown

• 1 other identifier: RECHMPL21_0726
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of specific IgE directed against the food source and molecular allergens. The gold standard remains the oral provocation test, which is performed in a hospital environment. Once the diagnosis is made, an elimination diet is still considered as the cornerstone of treatment for most food allergies. While some allergies, such as cow's milk or egg, tend to resolve spontaneously, others, such as allergy to pecan nuts, show a tendency to be persistent. In addition, pecan allergy is often characterized by potentially serious clinical reactions, compared to other foods, which can even be life threatening. In our clinical practice, the investigators found that patients with allergies to pecan nuts often present with severe hypersensitivity reactions when challenged orally to this food. Beyond this information, there are few studies regarding pecans. The investigators decided to retrospectively evaluate the results of oral food challenge and of the allergy work-up in our patients sensitized and allergic to pecan nuts, to better understand the current epidemiology of such food allergy.

Conditions

Allergic Reaction

Keywords

Sensitization to pecan nut (specific IgE and/or skin prick tests); Challenge proven pecan allergy; Allergic Comorbidities; Oral food challenge; Anaphylaxis

Outcome Measures

Primary Outcomes (1)

• Prevalence of challenge-proven pecan allergy

  Prevalence of challenge-proven pecan allergy in sensitized patients

  day 1

Secondary Outcomes (2)

• Epidemiological characteristics of pecan allergic patient

  day 1

• cut-off of specific IgE

  day 1

Eligibility Criteria

• Age: 5 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients consulting in the Allergy Unit of the Arnaud de Villeneuve Hospital, sensitized to pecan nut, and having undergone an oral food challenge to this food allergen

You may qualify if:

• Patients assessed for pecan allergy, through oral food challenge, from January 2000 to december 2021, at the University Hospital of Montpellier
• Patients with a positive skin prick test and/or positive specific IgE to pecan nut

You may not qualify if:

• Patients not affiliated to French Social Security
• Patients not capable of understanding French
• Patients sensitized to pecan nut, who did not perform an oral food challenge to this food allergen

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

RECRUITING

MeSH Terms

Conditions

Hypersensitivity; Anaphylaxis

Condition Hierarchy (Ancestors)

Immune System Diseases; Hypersensitivity, Immediate

Study Officials

• Davide CAIMMI

  University Hospital, Montpellier

  STUDY DIRECTOR

Central Study Contacts

Davide CAIMMI, MD

CONTACT

467336112; davide.caimmi@gmail.com

Audrey GOPAL, MD

CONTACT

467336107; gopal@chu-montpellier.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 22, 2021
• First Posted: January 11, 2022
• Study Start: November 1, 2021
• Primary Completion: January 1, 2022
• Study Completion: April 1, 2022
• Last Updated: January 11, 2022

Record last verified: 2021-12

Locations

FR (1)