The Canadian Respiratory Research Network Long COVID-19 Study

NCT05181670 | Completed

• 1 other identifier: 177755
• Study Type: observational
• Target: 450
• Locations: 1 country
• Sites: 8

Brief Summary

Preliminary studies suggest that COVID-19 causes long-term lung damage, even in young, otherwise healthy people who did not need to go to hospital or the ICU. We seek to know how common long-term lung damage after COVID-19 is, who is most affected by it and what the effects of this damage are on other important aspects of people's lives. We plan to study a large sample of people with a history of COVID-19 infection from across Canada-some who needed hospitalization but most who did not. Through online questionnaires, we will determine their respiratory symptoms, quality of life and medical history. Then we will invite them to one of our thirteen Canadian testing centres to have special, thorough breathing tests. We hypothesize that COVID-19 leaves a significant proportion of people with measurable respiratory impairment. The information we learn about the effect of COVID-19 on the lungs will help patients and health care providers manage it better. It will also reveal how different COVID-19 variants affect the lungs. We will use this new knowledge to write a formal guide on what respiratory monitoring and testing should be done after COVID-19 infection. This will ensure that people affected by COVID-19 get the care they need to maintain their lung health.

Conditions

SARS-CoV-2 Infection; Post-acute Sequelae of SARS-CoV-2

Outcome Measures

Primary Outcomes (1)

• To determine the prevalence of respiratory post-acute sequelae of SARS-CoV-2 (PASC) and PASC

  At five-12 months post positive PCR test for SARS-CoV-2 infection

Secondary Outcomes (3)

• To determine risk factors for respiratory PASC

  At five-12 months post positive PCR test for SARS-CoV-2 infection

• To determine the spectrum of severity of respiratory PASC

  At five-12 months post positive PCR test for SARS-CoV-2 infection

• To determine objective physiologic characteristics of respiratory PASC

  At five-12 months post positive PCR test for SARS-CoV-2 infection

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Community sample

You may qualify if:

• Aged ≥18
• Community dwelling
• First occurrence of a positive diagnostic test for SARS-CoV-2 infection (i.e., PCR or rapid antigen test, including at-home rapid antigen test) and symptomatic infection 5-12 months previously
• Consent provided
• Willing and able to go to study site for pulmonary function testing including oscillometry

You may not qualify if:

• \- Not able to communicate with our research personnel (themselves or through a translator)

Sponsors & Collaborators

• Sunnybrook Health Sciences Centre: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (8)

St. Paul's Hospital

Vancouver, British Columbia, Canada

Location

Queen Elizabeth II Health Sciences Centre

Halifax, Nova Scotia, Canada

Location

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada

Location

Kingston Health Sciences Centre

Kingston, Ontario, Canada

Location

The Ottawa Hospital

Ottawa, Ontario, Canada

Location

Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada

Location

St. Michael's Hospital

Toronto, Ontario, Canada

Location

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Québec, Canada

Location

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Andrea Gershon, MD, MSc

  Sunnybrook Health Sciences Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Scientist and Respirologist

Study Record Dates

• First Submitted: January 4, 2022
• First Posted: January 6, 2022
• Study Start: August 1, 2022
• Primary Completion: June 30, 2024
• Study Completion: June 30, 2024
• Last Updated: May 21, 2025

Record last verified: 2025-05

Locations

CA (8)