Influencing Factors of Coronary Heart Disease in Young People

NCT05175495 | Unknown DMC

• 1 other identifier: Observational
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Conditions

Coronary Heart Disease

Keywords

Coronary heart disease; Inflammatory cytokines; lifestyle; Familial inheritance; Myocardial infarction

Outcome Measures

Primary Outcomes (3)

• Whether inflammatory factors are differentially expressed in young patients with coronary heart disease

  The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing.

  Until April 2024

• The effect of gene activity on youth morbidity

  The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene

  Until April 2024

• Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people

  The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results

  Until April 2024

Study Arms (3)

Normal young

Aged less than 45 years old,no underlying heart disease

Young people diagnosed with coronary heart disease

Aged less than 45 years old,Diagnosed coronary heart disease;Confirmed by coronary angiography;Diagnosed myocardial infarction;Typical symptom of ischemic chest pain with positive stress test;

Coronary heart disease

Older than 65 years, diagnosed with coronary heart disease

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Diagnosed coronary heart disease

You may qualify if:

• Diagnosed coronary heart disease
• Confirmed by coronary angiography
• Diagnosed myocardial infarction
• Willing to sign an inform consent

You may not qualify if:

• Patients won't sign an inform consent or will not comply with the follow up.

Sponsors & Collaborators

• Hongzhuan Sheng: lead
• Affiliated Hospital of Nantong University: collaborator

Study Sites (1)

shengHz

Nantong, Jiangsu, 226000, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood、serum、plasma

MeSH Terms

Conditions

Coronary Disease; Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• hzh sheng, Dr.

  Affiliated Hospital of Nantong University

  STUDY CHAIR

Central Study Contacts

hzh sheng, Dr.

CONTACT

13515203348; yjshz@ntu.edu.cn

H L, A master's degree

CONTACT

18351328050; 898571711@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Chief physician

Study Record Dates

• First Submitted: November 5, 2021
• First Posted: January 3, 2022
• Study Start: August 1, 2021
• Primary Completion: August 1, 2024
• Study Completion: August 1, 2024
• Last Updated: July 25, 2023

Record last verified: 2023-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)