The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation
Comparing the Acute Effects of Exercise and Caffeine on Working Memory During a Short Period of Caffeine Deprivation in Moderate to Heavy Caffeine Consumers
1 other identifier
interventional
7
1 country
1
Brief Summary
To determine the effects of moderate intensity exercise and caffeine on working memory in deprived caffeine consumers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_2
Started Jan 2022
Shorter than P25 for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 10, 2021
CompletedFirst Posted
Study publicly available on registry
December 28, 2021
CompletedStudy Start
First participant enrolled
January 10, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2022
CompletedMarch 4, 2024
February 1, 2024
3 months
December 10, 2021
February 29, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
Change in Working Memory as assessed by N-back task
Participants will complete three n-back assessments, one baseline, one after 24 hours of caffeine deprivation, and one after treatment (either caffeine ingestion or acute exercise). Percent error rates will be compared.
Baseline and 24 hours later (deprived and post-treatment).
Study Arms (2)
Acute Exercise
EXPERIMENTAL20 minutes of moderate intensity acute exercise (treadmill speed to achieve ⅔ of maximum heart rate).
Caffeine Ingestion
ACTIVE COMPARATOR1.2mg/kg of powdered caffeine (Caffeine powder, ReagentPlus® from Sigma-Aldrich) dissolved in 1 cup of water then sitting for 20 minutes.
Interventions
Brisk walking on a treadmill at ⅔ maximum heart rate as defined by 220-age (in years).
Participants will receive powdered caffeine dissolved in one cup of water (1.2mg/kg)
Eligibility Criteria
You may qualify if:
- Are over the age of 18 years
- Consume at least 150 mg of caffeine a day
- Do not have any cognitive problems
- Are not pregnant
- Do not have a medical condition that prevents you to exercise
- Do not have an orthopaedic limitation
- Have access to a telephone or an email account for communication
- Can read and write in English
You may not qualify if:
- Participants taking prescription medication for depression or anxiety
- Participants that cannot give informed consent will be excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The University of Western Ontario
London, Ontario, Canada
Related Publications (1)
Morava A, Fagan MJ, Prapavessis H. Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal. Sci Rep. 2019 Dec 23;9(1):19644. doi: 10.1038/s41598-019-56251-y.
PMID: 31873185BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Harry Prapavessis, PhD
Western University
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor, School of Kinesiology
Study Record Dates
First Submitted
December 10, 2021
First Posted
December 28, 2021
Study Start
January 10, 2022
Primary Completion
March 31, 2022
Study Completion
April 1, 2022
Last Updated
March 4, 2024
Record last verified: 2024-02