The Correlation Between the Metabolism and the Functional Status of Multiple Organs in the Early Stage of Diquat Poisoning

NCT05168111 | Unknown DMC

• 1 other identifier: 2021-1068
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Diquat (DQ), as a conductive biocidal herbicide, is classified as medium according to Chinese pesticide toxicity classification standards. Since the sale and use of paraquat are stopped in 2016, incidents of diquat poisoning have begun to increase. Diquat is very toxic to the human body. Mistake of Diquat can cause damage to multiple organs throughout the body. It has a high fatality rate and no specific treatment.The treatment method has become a research hotspot of modern poisoning treatment. The degree of organ dysfunction caused by DQ poisoning is mainly related to the patient's intake and the distribution of the poison in the human body.So far, the distribution concentration of DQ under the influence of the time gradient in the body and the influence of DQ on the human environment，metabolimics,，immune regulation activity and the comprehensive mechanism of action of various inflammatory factors have not been fully elucidated. Therefore, this research mainly focuses on analyzing the internal environment metabolism research in patients with DQ poisoning, and to conduct exploratory research on the severity of the impact on their organ functions

Conditions

Diquat Poisoning

Keywords

Diquat Metabolomics Toxicology Multicenter

Outcome Measures

Primary Outcomes (1)

• The poison metabolomics of Diquat

  Improve the correlation between the concentration and metabolism rate of diquat poisoning in vivo and metabolomics and the co-damage color of body organs for bioinformatics analysis and summary

  2022-06

Study Arms (2)

patients of Diquat poisoning

Diagnostic Test: Detect the serum sample

normal persons

Diagnostic Test: Detect the serum sample

Interventions

Detect the serum sample DIAGNOSTIC_TEST

Detect the serum sample

normal persons; patients of Diquat poisoning

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute poisoning of diquat are mainly selected.

You may qualify if:

• Time from poisoning to hospital admission: within 6 hours, 2 The age is greater than 18 years old, less than 65 years old 3 There is at least one target organ dysfunction 4 Previous physical fitness 5 No bad habits (drug use, alcohol addiction)

You may not qualify if:

• Refuse to join this study
• Missing/incomplete information
• Pregnant women, vulnerable groups such as those who have no capacity for civil conduct and cannot determine the consent of their attorneys
• Chronic organ dysfunction (chronic heart insufficiency, chronic respiratory insufficiency, chronic renal insufficiency, chronic Liver insufficiency)
• Tumors, blood system diseases, various systemic immune diseases
• Various infectious diseases (various hepatitis, tuberculosis, AIDS)

Sponsors & Collaborators

• Second Affiliated Hospital, School of Medicine, Zhejiang University: lead

Study Sites (1)

SAHZU

Hanzhou, Zhejiang, 310009, China

RECRUITING

Study Officials

• Yongan Xu

  SAHZU

  STUDY DIRECTOR

Central Study Contacts

Yongan Xu, Doctor

CONTACT

13757164833; xuyongan2000@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2021
• First Posted: December 23, 2021
• Study Start: December 2, 2021
• Primary Completion: June 30, 2022
• Study Completion: June 30, 2022
• Last Updated: December 23, 2021

Record last verified: 2021-12

Locations

CN (1)