Identifying Reasons for Non-adherence in Patients With Multi-morbidity

NCT05167578 | Unknown

• 2 other identifiers: HUS/1037/2020VD/4977/13.00.00/2020
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

The study will be carried out during pharmacist-conducted medication reconciliation. The pharmacist will ask how the patient has been taking the prescribed medicines and whether any over-the-counter medicines and food supplements have been used for self-medication. The data will be analyzed for descriptive statistics to identify 1) the number of discrepancies between the physician's prescription orders and the patient's self-reported use of the medicines, 2) what kind of discrepancies there are, and 3) which of them negatively influence patients' medicine taking.

Conditions

Medication Adherence; Medication Nonadherence; Chronic Disease

Keywords

medication adherence; nonadherence; self-management; chronic disease; multimorbidity; primary care; medication reconciliation; pharmacist; public health

Outcome Measures

Primary Outcomes (1)

• Medication discrepancy

  Comparison of actual use of medicines versus prescribed medicines

  Through study completion, an average of 3 months

Secondary Outcomes (3)

• The groups of medicines

  Through study completion, an average of 3 months

• The reason for non-adherence

  Through study completion, an average of 3 months

• The effectiveness of medication information

  Through study completion, an average of 3 months

Study Arms (1)

Patients with multimorbidity

Patients with multimorbidity who visit the public health centres in Vantaa, Southern Finland

Behavioral: Medication reconciliation

Interventions

Medication reconciliation BEHAVIORAL

A pharmacist will go through all medicines physicians have prescribed, over-the-counter medicines (OTC) and food supplements one by one to assess the actual medicine used by the patient. If a pharmacist identifies medication discrepancies between physician's prescriptions and patient's self-reported use of medicine during the medication reconciliation, she/he will find out the patients' reasons for adjusting the medication.

Patients with multimorbidity

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with chronic conditions and multiple medication who visit the public health centres in Vantaa, Southern Finland

You may qualify if:

• Patients with multimorbidity
• Patients with ≥5 prescription medicines
• Finnish speaking
• Living at home and managing daily life independently
• Willingness to take part and sign the informed consent

You may not qualify if:

• Patients not understand Finnish
• Diagnosed Alzheimer or another memory disorder
• Need help to manage daily life
• End of life care

Sponsors & Collaborators

• Helsinki University Central Hospital: lead

Study Sites (1)

Vantaa healthcare and social services

Vantaa, 01030, Finland

RECRUITING

Related Publications (1)

• Kvarnstrom K, Westerholm A, Airaksinen MS, Liira H. Why medicines are used differently from prescribed: a protocol for a prospective patient-oriented observational case study to investigate reasons for non-adherence in primary care. BMJ Open. 2022 Dec 22;12(12):e065363. doi: 10.1136/bmjopen-2022-065363.

  PMID: 36549723 DERIVED

MeSH Terms

Conditions

Medication Adherence; Chronic Disease

Interventions

Medication Reconciliation

Condition Hierarchy (Ancestors)

Patient Compliance; Patient Acceptance of Health Care; Treatment Adherence and Compliance; Health Behavior; Behavior; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Medication Errors; Drug Therapy; Therapeutics; Medical Errors; Health Services; Health Care Facilities Workforce and Services; Medication Systems; Organization and Administration; Health Services Administration; Patient Care Management

Study Officials

• Marja Airaksinen, PhD Pharm

  STUDY DIRECTOR

Central Study Contacts

Kirsi MK Kvarnström, MScPharm

CONTACT

+358 40 656 9057; kirsi.kvarnstrom@hus.fi

Helena Liira, MD

CONTACT

helena.liira@hus.fi

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 4 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior pharmacist in charge

Study Record Dates

• First Submitted: November 19, 2021
• First Posted: December 22, 2021
• Study Start: April 15, 2021
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2024
• Last Updated: October 17, 2022

Record last verified: 2022-10

Locations

FI (1)