Training in a Local Community Aimed Upon Musculoskeletal Health Promotion for Postmenopausal Women

NCT05164679 | Completed

• 1 other identifier: Knoglestaerk
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength. However, the effectiveness of different training programmes performed in community settings remain uncertain. The present study aimed to evaluate the feasibility and the effectiveness of 19-week of multimodal training in a local community center in Copenhagen, Denmark. The health promotion initiative had special emphasis on musculoskeletal health in postmenopausal women.

Conditions

Age-Related Osteoporosis

Keywords

Bone mineral density; bone turnover marker; high-impact; odd-impact; resistance exercise; menopause; health promotion

Outcome Measures

Primary Outcomes (4)

• Whole-body and regional BMD

  bone mineral density (g/cm2)

  19 weeks

• Osteocalcin

  Concentration of Osteocalcin in plasma in fasted state (µg/l)

  3 weeks and 19 weeks

• P1NP

  Concentration of P1NP in plasma in fasted state (µg/l)

  3 weeks and 19 weeks

• CTX

  Concentration of CTX in plasma in fasted state (ng/l)

  3 weeks and 19 weeks

Secondary Outcomes (9)

• Body fat percentage

  19 weeks

• Visceral adipose tissue (VAT)

  19 weeks

• Body weight

  19 weeks

• BMI

  19 weeks

• Total fat mass

  19 weeks

Study Arms (2)

MMT

EXPERIMENTAL

Intervention group performing multimodal training (MMT) 1-2 hours weekly

Behavioral: multimodal training (MMT)

CON

NO INTERVENTION

Sedentary control group

Interventions

multimodal training (MMT) BEHAVIORAL

Supervised multimodal exercise training (MMT) performed 1-2 hours weekly for 19 weeks

Also known as: Sedentary control group (CON)

MMT

Eligibility Criteria

• Age: Up to 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• past menopause
• non-smoking
• BMI \<30 kg/m2

You may not qualify if:

• T-score \< -3 SD in the lumbar spine or hip
• Z-score \> 1.5 SD)
• use of hormone therapy, medical treatment or supplements that affect bone metabolism
• previous or current medical condition affecting bone health
• engagement in regular and systemic weight-bearing training or strength training during the preceding two years

Sponsors & Collaborators

• University of Copenhagen: lead

Study Sites (1)

University of Copenhagen, Department of Nutrition, Exercise and Sports

Copenhagen, 2200, Denmark

Location

Related Publications (1)

• Prawiradilaga RS, Bendtsen M, Esrup S, Jorgensen NR, Yulianto FA, Helge EW. Feasibility Study of Community-Based Training for Musculoskeletal Health Promotion. F1000Res. 2024 Sep 4;11:51. doi: 10.12688/f1000research.73698.3. eCollection 2022.

  PMID: 39263388 DERIVED

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Eva W Helge, Ph.D.

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Ph.D.

Model Details: Healthy, sedentary postmenopausal women aged below 70 years were eligible to participate in the present study. Inclusion criteria were: * non-smoker * body mass index (BMI) \<30 kg/m2. Exclusion criteria were: * T-score \< -3 SD in the lumbar spine or hip * high BMD in relation to age (Z-score \> 1.5 SD) * use of hormone therapy, medical treatment, or supplements that affect bone metabolism * previous or current medical condition affecting bone health * engagement in regular and systematic weight-bearing training or strength training during the preceding two years. Initially, twenty women were recruited to the training via an online advertisement and a local newspaper, but only 19 showed up for pre-testing. After a medical examination, one participant was excluded due to low BMD (T-score \< -3 SD), and two were excluded due to high BMI (≥30 kg/m2).

Study Record Dates

• First Submitted: December 4, 2021
• First Posted: December 21, 2021
• Study Start: January 4, 2019
• Primary Completion: July 9, 2019
• Study Completion: July 9, 2019
• Last Updated: December 21, 2021

Record last verified: 2021-12

Locations

DK (1)