Genetic Susceptibility to Periprosthetic Joint Infections

NCT05159739 | Enrolling By Invitation DMC

• 1 other identifier: 95940
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators primary objective is to identify genetic factors that may increase the risk of patients developing a periprosthetic joint infections (PJI) following total joint arthroplasty (TJA). The investigators hope that by identifying genetic predispositions we will be able to provide patient specific care pathways to prevent or minimize the risk for PJI.

Conditions

Total Joint Arthroplasty; Periprosthetic Joint Infections

Keywords

total joint arthroplasty; periprosthetic joint infections; genetic susceptibility

Outcome Measures

Primary Outcomes (1)

• Genotyping

  Samples will undergo genetic testing to determine the presence or absence of potential candidate genes responsible for the increased incidence of PJI.

  DNA extraction and analysis will be performed immediately after collection of blood draw or saliva/cheek cell sample by a certified core lab

Study Arms (1)

Total Joint Arthroplasty (TJA)

Recruitment of families with an increased incidence of TJI with PJI.

Genetic: Blood Draw or Saliva/Cheek Cell Sample:

Interventions

Blood Draw or Saliva/Cheek Cell Sample: GENETIC

Collected samples will immediately undergo genetic analysis to determine the presence or absence of potential candidate genes responsible for the increased incidence of PJI.

Also known as: Genetic sample

Total Joint Arthroplasty (TJA)

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Family members (affected and unaffected) with an increased incidence of TJI with PJI.

You may qualify if:

• Families/pedigrees which demonstrate a high-risk for PJI
• Unaffected family members, up to 3rd degree

You may not qualify if:

• None

Sponsors & Collaborators

• University of Utah: lead

Study Sites (1)

University of Utah Orthopaedic Center

Salt Lake City, Utah, 84108, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood Draw or Saliva/Cheek Cell Sample

MeSH Terms

Conditions

Genetic Predisposition to Disease

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Jeremy Gililland, M.D.

  University of Utah

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: December 2, 2021
• First Posted: December 16, 2021
• Study Start: March 7, 2018
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: March 19, 2026

Record last verified: 2026-03

Locations

US (1)