Study on the Difference and Cause of Acupuncture Dexmedetomidine Compound Anesthesia Effect

NCT05159674 | Unknown DMC

• 1 other identifier: 2021.11.30
• Study Type: interventional
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

Studies have shown that the use of dexmedetomidine before and during surgery has a good sedative, analgesic and circulatory stabilizing effect. The use of dexmedetomidine in thoracoscopic lung resection has been proven to be safe and feasible, and it has a certain degree of improvement in postoperative lung function. Combining the advantages of thoracoscopy and the previous experience of combined acupuncture and drug anesthesia technology, our team pioneered cardiopulmonary surgery without endotracheal intubation and combined needle and drug anesthesia, so that the patient was in a state of light sleep and spontaneous breathing without tracheal intubation. After completing the operation, it was found that this technical method can effectively reduce the amount of intraoperative anesthetics, improve intraoperative lung ventilation, improve lung oxygenation, achieve intraoperative organ protection, and significantly reduce complications caused by tracheal intubation , Postoperative analgesic drugs have reduced the amount of 20%, accelerate the time of exhaust and defecation, and its postoperative rehabilitation is better than conventional treatment. These results suggest that the combination of acupuncture and medicine is not only suitable for anesthesia, it can be used scientifically and rationally in postoperative analgesia, immune regulation and even the entire perioperative organ protection, creating more possibilities for patients' ERAS. In combined acupuncture and drug anesthesia, the core goal is to use acupuncture to reduce the insufficiency of anesthetics in terms of analgesia, sedation, stable circulation, and protection of organs. However, the mechanism of action behind this type of combination has not yet been improved. Efficacy kinetics or pharmacokinetics has been explained convincingly, or it is not well recognized. For example, is there a specific target in the body of acupuncture? If there is a specific target, where is the effect target? If the combined application of acupuncture and medicine produces a synergistic effect through a pharmacokinetic mechanism, its specific mechanism still needs to be clarified.

Conditions

Acupuncture; Dexmedetomidine; Anesthesia

Keywords

Acupuncture; Dexmedetomidine; Combined anesthesia; Metabolic enzyme

Outcome Measures

Primary Outcomes (1)

• Time required for bispectral index of EEG to be less than 80

  The time required for bispectral index of EEG in the intervention group was lower than that in the non intervention group

  From the time anesthesia was given until the end time of the surgery

Study Arms (2)

Dexmedetomidine+electroacupuncture compound anesthesia

EXPERIMENTAL

EA was given every day three days before surgery, 30 minutes before induction of anesthesia + the whole course of surgery, and every 12 hours from the first day after surgery, each treatment was performed for 30 minutes until 48 hours after surgery. During the operation, only dexmedetomidine was used to make BIS\<80.

Device: Dexmedetomidine+electroacupuncture compound anesthesia

Dexmedetomidine anesthesia

NO INTERVENTION

There was no EA treatment before, during or after operation. During the operation, only dexmedetomidine was used to make BIS\<80.

Interventions

Dexmedetomidine+electroacupuncture compound anesthesia DEVICE

Dexmedetomidine and acupuncture were given together to induce anesthesia

Dexmedetomidine+electroacupuncture compound anesthesia

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with pulmonary nodules scheduled for thoracoscopic surgery;
• Age ≥ 18 and ≤ 75, regardless of gender;
• Understand and agree to participate in this study and sign the informed consent form.

You may not qualify if:

• Patients who have previously received EA treatment;
• Patients with skin infection at acupoints;
• Patients with nerve injury of upper or lower limbs;
• Those who have participated or are participating in other clinical trials one month before enrollment.

Sponsors & Collaborators

• Shanghai Yueyang Integrated Medicine Hospital: lead
• Shanghai University of Traditional Chinese Medicine: collaborator

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2021
• First Posted: December 16, 2021
• Study Start: December 15, 2021
• Primary Completion: September 15, 2023
• Study Completion: December 15, 2023
• Last Updated: December 16, 2021

Record last verified: 2021-11