Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry

NCT05158751 | Not Yet Recruiting

• 1 other identifier: KCHRF-MAVERIC REG-0009
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.

Conditions

Myocarditis; Premature Ventricular Contractions; Ventricular Tachycardia (VT)

Outcome Measures

Primary Outcomes (1)

• Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF

  To identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF through laboratory testing, FDG-PET(18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose - positron emission tomography) scan, Cardiac Magnetic Resonance imaging and/or Endomyocardial biopsy.

  Retrospective Collection between dates January 2014-January 2023

Secondary Outcomes (1)

• Ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes

  Retrospective Collection between dates January 2014-January 2023

Other Outcomes (1)

• Evaluate whether IST + catheter ablation results in optimal clinical response

  Retrospective Collection between dates January 2014-January 2023

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Males and females with PVC and ventricular tachycardia (VT) will be enrolled if they meet the inclusion/exclusion criteria

You may qualify if:

• Patients \> 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
• Non-sustained VT was defined as ≥3 more consecutive beats lasting \<30 seconds

You may not qualify if:

• History of myocardial infarction,
• Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
• History of revascularization,
• Significant symptomatic atrial arrhythmias associated with LV dysfunction,
• Severe valvular disease,
• Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
• History of cardiac arrest,
• History of channelopathies or inherited arrhythmias.

Sponsors & Collaborators

• Kansas City Heart Rhythm Research Foundation: lead
• Kansas City Heart Rhythm Institute: collaborator

Study Sites (1)

Kansas City Heart Rhythm Institute

Overland Park, Kansas, 66211, United States

Location

Related Publications (32)

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MeSH Terms

Conditions

Myocarditis; Ventricular Premature Complexes; Tachycardia, Ventricular

Condition Hierarchy (Ancestors)

Cardiomyopathies; Heart Diseases; Cardiovascular Diseases; Cardiac Complexes, Premature; Arrhythmias, Cardiac; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Tachycardia

Study Officials

• Dhanunjaya Lakkireddy, MD

  Kansas City Heart Rhythm Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Donita Atkins

CONTACT

816-651-1969; datkins@kchrf.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2021
• First Posted: December 15, 2021
• Study Start: January 1, 2026
• Primary Completion: March 1, 2026
• Study Completion: May 1, 2026
• Last Updated: September 4, 2025

Record last verified: 2024-10

Locations

US (1)