Elevated Liver Enzymes as a Predictor of Acute Kidney Injury in Hospitalized Patients With COVID-19

NCT05157152 | Unknown DMC

• 1 other identifier: Soh-Med-21-12-10
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In critically ill patients, AKI is a common complication of COVID-19 infection, occurring in 23% to 43% of cases, and was correlated with poor clinical outcomes. An increase in liver function tests ( LFTs) has been found in patients with COVID-19 ranging 14%-75% Some studies found higher levels of transaminases in patients with severe COVID-19 pneumonia and in patients dying for COVID-19. Initial reports indicate a high incidence of abnormal liver tests and acute kidney injury (AKI) in the novel coronavirus infection (COVID-19). We hypothesis that there is a relationship between COVID-19 patients who are critically ill, liver enzymes and level of serum creatinine

Conditions

COVID-19 Pandemic

Outcome Measures

Primary Outcomes (1)

• Relationship between liver enzymes and AKI in patients with COVID19

  Elevated Liver Enzymes as a predictor of Acute Kidney Injury in hospitalized patients with COVID-19

  4 months

Secondary Outcomes (1)

• Severity of COVID19 infection

  4 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with respirator symptoms of COVID-19 admitted at Sohag university hospital

You may qualify if:

• Patients who are positive for COVID-19 infection in Sohag University Hospital whose ages \< 18 years old. (confirmed by polymerase chain reaction (PCR) from nasopharyngeal or oropharyngeal samples) who developed AKI at time of admission or during admission.

You may not qualify if:

• Patients whose ages \>18 years old.
• Patients known to have any liver disease.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

SOHAGU

Sohag, 28511, Egypt

RECRUITING

Related Publications (1)

• Ngiam JN, Chew N, Tham SM, Lim ZY, Li TY, Cen S, Tambyah PA, Santosa A, Muthiah M, Sia CH, Cross GB. Elevated liver enzymes in hospitalized patients with COVID-19 in Singapore. Medicine (Baltimore). 2021 Jul 30;100(30):e26719. doi: 10.1097/MD.0000000000026719.

  PMID: 34397705 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Liver enzymes, serum creatinine, CBC, PCR

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ahmed Ka Osman, Resident

  Sohag university-faculty of medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Ka Osman, Resident

CONTACT

+201090784895; ahmed011028@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor at internal medicine department, sohag university hospital

Study Record Dates

• First Submitted: December 12, 2021
• First Posted: December 14, 2021
• Study Start: January 1, 2022
• Primary Completion: April 30, 2022
• Study Completion: May 30, 2022
• Last Updated: December 14, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: April 2022 forever
• Access Criteria: Any One have access

Locations

EG (1)