Cognitive, Emotional and Behavioural Impairments in Patients After Sars-Cov2 Infection

NCT05143320 | Completed

• 1 other identifier: NPS impairment in Covid-19
• Study Type: observational
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Recent studies suggest cognitive, emotional and behavioural impairments occur in patients after SARS-CoV-2 infection. Problems with memory, attention, information processing and executive functions are particularly prevalent in these patients, probably due to hypothesised sensitivity of the hippocampus to the virus. Cognitive impairment is also present in patients with no neurological, neuropsychological and neuropsychiatric history. Therefore, the aim of the present study is to describe neuropsychological and neuropsychiatric features in patients recovered from moderate to severe forms of Covid-19 some weeks after hospital dismission.

Conditions

COVID-19; Sars-CoV-2 Infection

Keywords

Covid-19; Cognition; Teleneuropsychology; Memory; Executive Functions

Outcome Measures

Primary Outcomes (1)

• Cognitive and neuropsychiatirc symptoms in Covid-19 patients

  Prevalence of neuropsychological and neuropsychiatric impairment in patients after hospitalization in patients with Sars-Cov2 infection.

  About 20 days after hospital dismission

Study Arms (2)

Covid+

Covid-

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who were hospitalized in the Covid ward and recovered from the acute phase of Covid-19 with no need of ICU admission. All patients had SARS-Cov-2 infection confirmed by positive PCR from nasopharyngeal swab. Neuropsychological study was performed on average 20 days after hospital discharge to have the most recent possible cognitive profile related to the infection. We enrolled 29 healthy controls (Covid-) who did not have SARS COV 2 infections with a 1:1 match by age, education and gender.

You may qualify if:

• Positive PCR from nasopharyngeal swab
• No ICU admission

You may not qualify if:

• Diagnosis of neurologic or psychiatric disorders;
• Previous cognitive impairment;
• Other medical conditions negatively affecting the cognitive status.

Sponsors & Collaborators

• Ospedale Generale Di Zona Moriggia-Pelascini: lead

Study Sites (1)

"Moriggia Pelascini" Hospital

Gravedona, Como, 22015, Italy

Location

Related Publications (1)

• Cian V, De Laurenzis A, Siri C, Gusmeroli A, Canesi M. Cognitive and Neuropsychiatric Features of COVID-19 Patients After Hospital Dismission: An Italian Sample. Front Psychol. 2022 May 24;13:908363. doi: 10.3389/fpsyg.2022.908363. eCollection 2022.

  PMID: 35686079 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 2, 2021
• First Posted: December 3, 2021
• Study Start: January 8, 2021
• Primary Completion: May 21, 2021
• Study Completion: October 29, 2021
• Last Updated: December 3, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)