Peripheral Venous Catheter Related Blood Stream Infections

NCT05139628 | Unknown

• 1 other identifier: PVC related BSIs
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this work is to:

1. 1.Study the impact of PIVC skin colonization on catheter tip colonization and the development of CRBSI
2. 2.isolate and identify the organisms causing peripheral venous catheter related blood stream infections in pediatric oncology patients.
3. 3.perform antimicrobial sensitivity testing of isolated organisms.
4. 4.identify the associated risk factors that lead to CRBSIs in such group of patients.

Conditions

Catheter-Related Infections

Outcome Measures

Primary Outcomes (1)

• Study the impact of Peripheral intravenous catheter skin colonization on catheter tip colonization and the development of Catheter related blood stream infections in pediatric oncology patients and Identify the associated risk factors.

  Isolate and identify the organisms causing CRBSIs and perform antimicrobial sensitivity testing of the isolated organisms.

  1 year (Anticipated)

Interventions

microbiological identification of samples (skin and blood samples) DIAGNOSTIC_TEST

Samples will be plated on blood culture plates and will be confirmed biochemically. Complete Bacteriological diagnosis will be done. The TTP of each BC bottle will be recorded

Eligibility Criteria

• Age: 40 Days - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

• This study will be conducted on pediatric patients admitted to South Egypt Cancer Institute -Assiut University with more than 48hrs of catheter insertion.Patients ( age \> 40 days up to 18 years) from both sexes.

You may qualify if:

• The following data will be collected for each patient :
• Age
• Sex
• Type of malignancy
• PIVC location
• Antimicrobial use
• Parenteral nutrition
• Dwell-time
• The reason for removal (eg, treatment complete, PIVC complications, or suspected infection, or routinely (72-96 hours).

You may not qualify if:

• Patient with existing bloodstream infections.
• or those with any type of infections

Sponsors & Collaborators

• Assiut University: lead

Related Publications (13)

• El-Mahallawy H, Sidhom I, El-Din NH, Zamzam M, El-Lamie MM. Clinical and microbiologic determinants of serious bloodstream infections in Egyptian pediatric cancer patients: a one-year study. Int J Infect Dis. 2005 Jan;9(1):43-51. doi: 10.1016/j.ijid.2003.11.010.

  PMID: 15603994 BACKGROUND

• Gaur A, Giannini MA, Flynn PM, Boudreaux JW, Mestemacher MA, Shenep JL, Hayden RT. Optimizing blood culture practices in pediatric immunocompromised patients: evaluation of media types and blood culture volume. Pediatr Infect Dis J. 2003 Jun;22(6):545-52. doi: 10.1097/01.inf.0000069762.44241.0d.

  PMID: 12799512 BACKGROUND

• Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011 Apr;9(4):244-53. doi: 10.1038/nrmicro2537.

  PMID: 21407241 BACKGROUND

• Hughes WT, Armstrong D, Bodey GP, Brown AE, Edwards JE, Feld R, Pizzo P, Rolston KV, Shenep JL, Young LS. 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Infectious Diseases Society of America. Clin Infect Dis. 1997 Sep;25(3):551-73. doi: 10.1086/513764.

  PMID: 9314442 BACKGROUND

• Kong HH. Skin microbiome: genomics-based insights into the diversity and role of skin microbes. Trends Mol Med. 2011 Jun;17(6):320-8. doi: 10.1016/j.molmed.2011.01.013. Epub 2011 Mar 4.

  PMID: 21376666 BACKGROUND

• Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977 Jun 9;296(23):1305-9. doi: 10.1056/NEJM197706092962301.

  PMID: 323710 BACKGROUND

• Norgaard M, Larsson H, Pedersen G, Schonheyder HC, Sorensen HT. Haematological malignancies--a predictor of a poor outcome in patients with bacteraemia. J Infect. 2006 Sep;53(3):190-8. doi: 10.1016/j.jinf.2005.10.024. Epub 2005 Dec 13.

  PMID: 16352338 BACKGROUND

• Rickard CM, Marsh N, Webster J, Runnegar N, Larsen E, McGrail MR, Fullerton F, Bettington E, Whitty JA, Choudhury MA, Tuffaha H, Corley A, McMillan DJ, Fraser JF, Marshall AP, Playford EG. Dressings and securements for the prevention of peripheral intravenous catheter failure in adults (SAVE): a pragmatic, randomised controlled, superiority trial. Lancet. 2018 Aug 4;392(10145):419-430. doi: 10.1016/S0140-6736(18)31380-1. Epub 2018 Jul 26.

  PMID: 30057103 BACKGROUND

• Safdar N, Maki DG. The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters. Intensive Care Med. 2004 Jan;30(1):62-7. doi: 10.1007/s00134-003-2045-z. Epub 2003 Nov 26.

  PMID: 14647886 BACKGROUND

• Sato A, Nakamura I, Fujita H, Tsukimori A, Kobayashi T, Fukushima S, Fujii T, Matsumoto T. Peripheral venous catheter-related bloodstream infection is associated with severe complications and potential death: a retrospective observational study. BMC Infect Dis. 2017 Jun 17;17(1):434. doi: 10.1186/s12879-017-2536-0.

  PMID: 28623882 BACKGROUND

• Soifer NE, Borzak S, Edlin BR, Weinstein RA. Prevention of peripheral venous catheter complications with an intravenous therapy team: a randomized controlled trial. Arch Intern Med. 1998 Mar 9;158(5):473-7. doi: 10.1001/archinte.158.5.473.

  PMID: 9508225 BACKGROUND

• Webster J, Osborne S, Rickard CM, Marsh N. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;1(1):CD007798. doi: 10.1002/14651858.CD007798.pub5.

  PMID: 30671926 BACKGROUND

• Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis. 2003 May 1;36(9):1103-10. doi: 10.1086/374339. Epub 2003 Apr 14.

  PMID: 12715303 BACKGROUND

MeSH Terms

Conditions

Catheter-Related Infections

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Infections

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Nahla M Elsherbiny, Prof. Dr.

  Professor of Medical Microbiology and Immunology Faculty of Medicine - Assiut University

  STUDY DIRECTOR

• Mona H Abdel-Rahim, A. prof.

  Assistant professor of Medical Microbiology and Immunology

  STUDY DIRECTOR

Central Study Contacts

Mariam M AbdelHafeez, MBBS

CONTACT

+201100862681; dr_mariam_h@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: November 18, 2021
• First Posted: December 1, 2021
• Study Start: July 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: July 1, 2024
• Last Updated: March 2, 2022

Record last verified: 2022-02