Monitoring Risks for Hematological Changes in Gas Station Workers

NCT05135078 | Unknown

• 1 other identifier: Soh-Med-21-10-08
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

Conditions

Hematologic Diseases

Outcome Measures

Primary Outcomes (5)

• The aim of study is to evaluate and monitor risks for hematological changes in gas station workers

  The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to complete blood count .

  within 6 months .

• The aim of study is to evaluate and monitor risks for hematological changes in gas station workers

  The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to liver function tests as alanine transaminase (ALT) measured by IU/L, aspartate transaminase (AST) measured by IU/L, total protein measured by gm/dl, albumin measured by g/dl and bilirubin measured by mg/dl.

  within 6 months .

• The aim of study is to evaluate and monitor risks for hematological changes in gas station workers

  The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to renal function tests as serum creatinine measured by mg/dl, serum urea measured by mg/dl and uric acid measured by mg/dl .

  within 6 months .

• The aim of study is to evaluate and monitor risks for hematological changes in gas station workers

  The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to CD45, CD34, HLA-DR, CD33, CD13, CD19, CD22, CD2, CD3, CD5, CD7, CD4, CD8, CD10, CD16 and CD65 measured by flowcytometry

  within 6 months .

• The aim of study is to evaluate and monitor risks for hematological changes in gas station workers

  The study will be conducted to a group of gas station workers exposed to benzene for more than 3 years, All workers will be subjected to ESR (Erythrocyte sedimentation rate) measured by mm .

  within 6 months ,

Eligibility Criteria

• Sex: male
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

gas station workers exposed to benzene more than 3 years

You may qualify if:

• This study will be conducted on a group of gas station workers exposed to benzene for more than 3 years .

You may not qualify if:

• diagnosed gas station workers with blood malignancies .
• gas station workers exposed to benzene for less than 3 years .

Sponsors & Collaborators

• Sohag University: lead

MeSH Terms

Conditions

Hematologic Diseases

Condition Hierarchy (Ancestors)

Hemic and Lymphatic Diseases

Central Study Contacts

Sara T taha

CONTACT

01020858495; sara011097@med.sohag.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator .

Study Record Dates

• First Submitted: October 14, 2021
• First Posted: November 26, 2021
• Study Start: December 1, 2021
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: November 26, 2021

Record last verified: 2021-10