Visual Performance With Spatial Light Modulator

NCT05134896 | Unknown

• 1 other identifier: STUDY00003209
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Eye's aberrations have been known to degrade human visual performance and the visual performance is significantly improved when correcting the aberrations in the central visual field. However, how the aberration correction affects the peripheral visual performance is not well understood. Moreover, how central and peripheral vision interacts remains unclear. To conduct the study, we will use an adaptive optics vision simulator equipped with a Shack-Hartmann wavefront sensor and a spatial light modulator (see details in procedures section of the protocol). This system is capable of noninvasively controlling the eye's optical quality and evaluating visual performance simultaneously over a wide area of visual space. This study provides insights into the visual performance in the periphery visual field, and interaction between central and peripheral visual fields. The goal of this study is to evaluate the visual performance at central and peripheral visual fields after correcting the ocular aberrations. An optical system equipped with a liquid crystal spatial light modulator will be used to achieve this goal non-invasively.

Conditions

Normal Healthy Eyes

Outcome Measures

Primary Outcomes (3)

• Visual acuity

  Snellen "Tumbling E" method will be used to determine the smallest letter that a subject can see.

  up to 6 separate sessions (each session taking up to 2 hours)

• Contrast sensitivity

  Light and dark sinusoidal stripes (Gabor gratings) will used to determine the smallest contrast that a subject can see

  up to 6 separate sessions (each session taking up to 2 hours)

• Contrast perception

  Light and dark sinusoidal stripes (Gabor gratings) will used to determine differences in contrast perceived by the central and peripheral visual system

  up to 6 separate sessions (each session taking up to 2 hours)

Study Arms (1)

normal healthy group

EXPERIMENTAL

Spatial light modulator

Device: Spatial light modulator

Interventions

Spatial light modulator DEVICE

This device compensates for the eye's optical imperfections (aberrations) at the foveal and peripheral retina.

normal healthy group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Is between the ages of 18 and 60.
• Has normal corneas i.e. no corneal infections, no systemic pink eye, no clinically significant dry eye, and no corneal dystrophies.
• Has refractive errors less than +/- 10.0 Diopters in both eyes.

You may not qualify if:

• A person will be excluded from the study if he/she:
• Adults between the ages of 18-60 who are unable to give informed consent
• Individuals below 18 years old
• Individuals above the age of 60
• Pregnant women (self-reporting, hormonal changes may alter the refractive status of the eye)
• Prisoners
• Students for whom you have direct access to/influence on grades
• People who do not understand or speak English
• Has clinically significant dry eye.
• Has clinically significant cataract.
• Has spherical refractive error that exceeds the limits outlined above.
• Is unable to hold his or her head steady for the duration of study measurements.

Sponsors & Collaborators

• University of Houston: lead

Central Study Contacts

Geunyoung Yoon, PhD

CONTACT

7137437860; gyoon2@central.uh.edu

Jiakai Lyu, MS

CONTACT

6262953929; jlyu@central.uh.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 11, 2021
• First Posted: November 26, 2021
• Study Start: November 1, 2021
• Primary Completion: November 1, 2022
• Study Completion: March 1, 2023
• Last Updated: November 26, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share