Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Versus Steroid/Anesthetic

NCT05121961 | Completed

• 1 other identifier: RSCH1923
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 2

Brief Summary

The purpose of this study is to determine if platelet-rich plasma is superior to steroid/anesthetic for the treatment of sacroiliac joint pain.

Conditions

Low Back Pain; Sacroiliac Joint Synovitis

Outcome Measures

Primary Outcomes (1)

• Numeric Rating Scale

  Validated pain scale rating pain on a scale of 0 through 10. 0 for no pain, and 10 for the highest pain the patient can imagine.

  Change between baseline and 3-months post-intervention

Secondary Outcomes (4)

• Modified Oswestry Disability Questionnaire

  Change between baseline and 3-months post-intervention

• Short-Form 12 Survey

  Change between baseline and 3-months post-intervention

• Functional testing

  Change between baseline and 3-months post-intervention

• Opiate/pain medication usage questionnaire

  Change between baseline and 3-months post-intervention

Study Arms (2)

Platelet-rich Plasma

EXPERIMENTAL

Patients will receive an intra-articular injection 3 mL of autologous platelet-rich plasma in the sacroiliac joint.

Procedure: Sacroiliac intra-articular injection

Steroid/Anesthetic

ACTIVE COMPARATOR

Patients will receive an intra-articular injection 40 mg Depo-medrol mixed with 2 mL 0.25% bupivicaine in the sacroiliac joint.

Procedure: Sacroiliac intra-articular injection

Interventions

Sacroiliac intra-articular injection PROCEDURE

CT guided injection of platelet-rich plasma versus steroid/anesthetic into the sacroiliac joint

Platelet-rich Plasma; Steroid/Anesthetic

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult (\>18 y/o) males and females referred for therapeutic injection to the investigators spine interventional service by a physiatrist or pain anesthesiologist with a clinical diagnosis of SIJ pain confirmed by history
• % or greater reduction in pain by a diagnostic anesthetic block using no more than 1.5 cc 2% lidocaine performed under imaging guidance by a pain interventionalist (PM\&R, Pain Anesthesia, or Neuroradiology Spine Intervention).
• Baseline pain must be \>/=4 by numeric rating scale (NRS), at least 6 weeks in chronicity, and must not be multi-factorial (related to radiculopathy or axial pain localizing elsewhere) by physical examination or confounding medical history (infection, inflammatory spondyloarthropathy, or osseous metastatic disease).

You may not qualify if:

• SIJ steroid treatment within the prior 6 months.
• Patients with a history of infection currently on antibiotic therapy
• Usage of systemic immunosuppressants
• Pregnancy

Sponsors & Collaborators

• University of Utah: lead
• Radiological Society of North America: collaborator

Study Sites (2)

University of Utah

Salt Lake City, Utah, 84132, United States

Location

Veterans Administration Salt Lake City Health Care System

Salt Lake City, Utah, 84148, United States

Location

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Miriam Peckham, MD

  University of Utah

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Patients will be blinded to which injectate they received.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Single-blind randomized controlled trial

Study Record Dates

• First Submitted: October 20, 2021
• First Posted: November 16, 2021
• Study Start: February 22, 2020
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: April 14, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)