Effects of Exercise on the Renin-angiotensin System

NCT05115383 | Unknown

• 1 other identifier: 117957
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Angiotensin converting enzyme-2 (ACE2) is part of the renin-angiotensin system (RAS), which is involved in maintaining blood flow and electrolyte balance. It has been shown in obese and hypertensive individuals that levels of another molecule Angiotensin converting enzyme (ACE) are much higher, leading to inflammation, fibrosis, vasoconstriction and high blood pressure. ACE2 has a protective effect from ACE, leading to anti-inflammatory, anti-fibrotic and vasodilating effects. In animal models, it has been shown that aerobic exercise can increase levels of ACE2, while decreasing levels of ACE and offers protection to the cardiovascular system by keeping these two molecules balanced. Although the effects of exercise on the classical arm of the RAS have been studied significantly, ACE2 is a relatively new discovery and has not been studied as extensively in humans. The purpose of this research is to determine the effects of exercise training status on the RAS, specifically on ACE2 and its products.

Conditions

COVID-19 Acute Respiratory Distress Syndrome

Outcome Measures

Primary Outcomes (1)

• Change in the mean response to an acute bout of physical activity in the components of the renin-angiotensin system

  Measurements of Angiotensin(1-10) and Angiotensin(1-9) will be analyzed using ELISA kits.

  measurements will be taken before, immediately post and 30 minutes post exercise.

Secondary Outcomes (1)

• Changes in the baseline measurements of the renin-angiotensin system between physically active and sedentary males.

  Measurements will be made prior to commencement of exercise protocols.

Study Arms (2)

Sedentary Group

ACTIVE COMPARATOR

Individuals who are physically active for less than 75 minutes of moderate to vigorous physical activity a week will be placed in the sedentary group.

Other: VO2 Max test

Active Group

ACTIVE COMPARATOR

Individuals who are physically active for greater than 150 minutes of moderate to vigorous physical activity will be placed in the active group.

Other: VO2 Max test

Interventions

VO2 Max test OTHER

The participant will be equipped with a vo2 mask or mouthpiece. They will get on the bike and begin with a 5 minute warmup ranging from 30-100 watts. After the warm up there will be a 15-30 watt increase every minute in the cadence that the participant is required to maintain. Once the participant has decided to stop pedalling, the participants mask will be removed to ensure they are feeling well. They will allowed to continue pedaling at their own pace for a cool down for up to two minutes.

Active Group; Sedentary Group

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• between the ages of 18-39
• ability to exercise to exhaustion
• ability to give informed consent

You may not qualify if:

• chronic consumption of recreational drugs, tobacco or alcohol
• on any prescription medication or anti-inflammatory medications
• diagnosed with any chronic conditions
• current diagnosis with COVID-19
• BMI \>30
• Engage in 75-150 minutes of moderate to vigorous physical activity a week

Sponsors & Collaborators

• Western University, Canada: lead

Study Sites (1)

Exercise Nutrition Laboratory, Western University

London, Ontario, N6A3K7, Canada

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2021
• First Posted: November 10, 2021
• Study Start: July 8, 2022
• Primary Completion: December 31, 2022
• Study Completion: April 30, 2023
• Last Updated: July 15, 2022

Record last verified: 2022-07

Locations

CA (1)