Symptom Scoring for Predicting Vocal Cord Dysfunction (VCD)

NCT05114083 | Withdrawn

• 1 other identifier: 2014H0368
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Dr. Russell Traister, et al, describes a symptom scoring system based on retrospective chart review to help identify subjects with VCD. Dr. Traister assigned the following symptom scores: dysphonia (2), throat tightness (4), sensitivity to odors (3) and absence of wheezing (2). Patients scoring 4 or more points have a positive predictive value of 96% and a negative predictive value of 77% for VCD. This prospective study will look at a population of patients presenting to a large tertiary care referral center for symptoms of cough. Patients seen at the "Cough Clinic" are evaluated by a Pulmonologist and an Otolaryngologist. Each patient undergoes pulmonary function testing and VLS testing as part of the diagnostic workup. For this study the history would be expanded to include the 4 specific symptoms: dysphonia, throat tightness, sensitivity to odors and absence of wheezing. The symptoms will be scored and compared against the results of diagnostic testing to determine if these symptoms help predict those with vocal cord dysfunction (VCD).

Conditions

Vocal Cord Dysfunction

Outcome Measures

Primary Outcomes (1)

• Determine if symptom scoring can accurately predict vocal cord dysfunction

  We will score each patient according to their symptoms of vocal cord dysfunction including; throat tightness (4 points), dysphonia (2 points), absence of wheezing (2 points), symptoms triggered by strong odors (3 points). A positive response will be assigned the score as indicated in parentheses behind each symptom. A negative response will be assigned zero points.

  1 year

Interventions

symptom assessment OTHER

symptom assessment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All participants male and female, age 18 years and older presenting as new patients to the Cough Clinic will be asked to participate if they are not attended by a guardian or an interpreter. Everyone (regardless if they choose to participate or not) will receive current standard practice/care of the Cough Clinic for evaluation, testing and treatment.

You may qualify if:

• All participants male and female,
• age 18 years and older
• presenting as new patients to the Cough Clinic

You may not qualify if:

• Participants less than 18 years of age and those attended by a guardian or an interpreter

Sponsors & Collaborators

• Ohio State University: lead

Related Publications (5)

• Parsons JP, Benninger C, Hawley MP, Philips G, Forrest LA, Mastronarde JG. Vocal cord dysfunction: beyond severe asthma. Respir Med. 2010 Apr;104(4):504-9. doi: 10.1016/j.rmed.2009.11.004. Epub 2009 Dec 4.

  PMID: 19962874 BACKGROUND

• Wilson JJ, Theis SM, Wilson EM. Evaluation and management of vocal cord dysfunction in the athlete. Curr Sports Med Rep. 2009 Mar-Apr;8(2):65-70. doi: 10.1249/JSR.0b013e31819def3d.

  PMID: 19276905 BACKGROUND

• Sterner JB, Morris MJ, Sill JM, Hayes JA. Inspiratory flow-volume curve evaluation for detecting upper airway disease. Respir Care. 2009 Apr;54(4):461-6.

  PMID: 19327180 BACKGROUND

• Benninger C, Parsons JP, Mastronarde JG. Vocal cord dysfunction and asthma. Curr Opin Pulm Med. 2011 Jan;17(1):45-9. doi: 10.1097/MCP.0b013e32834130ee.

  PMID: 21330824 BACKGROUND

• Traister RS, Fajt ML, Landsittel D, Petrov AA. A novel scoring system to distinguish vocal cord dysfunction from asthma. J Allergy Clin Immunol Pract. 2014 Jan-Feb;2(1):65-9. doi: 10.1016/j.jaip.2013.09.002. Epub 2013 Nov 2.

  PMID: 24565771 BACKGROUND

MeSH Terms

Conditions

Vocal Cord Dysfunction

Condition Hierarchy (Ancestors)

Laryngeal Diseases; Respiratory Tract Diseases; Respiration Disorders; Otorhinolaryngologic Diseases

Study Officials

• Jonathan Parsons, MD

  Ohio State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Internal Medicine

Study Record Dates

• First Submitted: September 24, 2015
• First Posted: November 9, 2021
• Study Start: January 1, 2017
• Primary Completion: October 1, 2021
• Study Completion: October 1, 2021
• Last Updated: November 9, 2021

Record last verified: 2021-10