Diagnosing Deep-vein Thrombosis Early in Critically Ill Patients
DETECT
1 other identifier
interventional
1,800
1 country
1
Brief Summary
The DETECT randomized controlled trial addresses the question of whether surveillance ultrasound in critically ill patients by facilitating DVT detection reduces the incidence of PE and lowers all-cause 90-day mortality. The primary outcome is 90-day all-cause mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2023
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 26, 2021
CompletedFirst Posted
Study publicly available on registry
November 9, 2021
CompletedStudy Start
First participant enrolled
March 21, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
ExpectedSeptember 19, 2025
September 1, 2025
2.9 years
October 26, 2021
September 15, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
90-day mortality
Mortality 90 days post randomization
90 days
Secondary Outcomes (3)
Proximal DVT
From randomization date to day 28 or ICU discharge whichever comes first
Pulmonary Embolism
From randomization date and throughout hospital stay up to day 28
Clinically important bleeding
From randomization date and throughout hospital stay up to day 90
Other Outcomes (3)
Mechanical ventilation-free days
28 days
Vasopressor-free days
28 days
Days alive and out of hospital by day 90
90 days
Study Arms (2)
Ultrasound Group
ACTIVE COMPARATORPatients will be receiving twice weekly proximal lower limb ultrasound
Control Group
NO INTERVENTIONProximal lower limb ultrasound will be performed as per the treating team discretion
Interventions
Twice weekly proximal lower limb ultrasound
Eligibility Criteria
You may qualify if:
- Medical, surgical or trauma ICU patients ≥18 years old.
- Patients who are expected to stay in the ICU more than 2 calendar days (unlikely to be discharged out of ICU on the day of admission or on the next day).
You may not qualify if:
- Patients with DVT or PE diagnosed within the last year.
- Patients receiving chronic systemic anticoagulation.
- Patients who have received up to the time of ICU admission or are receiving therapeutic doses of anticoagulation with UFH, LMWH, or other anticoagulants.
- Inability or contraindication to obtain adequate ultrasound on the lower extremities (Burns in the lower extremities, lacerations, active skin infection, \& ischemic limb in the legs, large dressings in the thighs that prevent adequate ultrasounds OR amputated foot or leg on one or two sides)
- Patients with Inferior Vena Cava (IVC) Filter.
- Known or suspected pregnancy.
- Limitation of life support, life expectancy \<7 days or palliative care.
- Previously enrolled in DETECT trial within the last 180 days.
- Enrolled in another trial for which co-enrolment is not approved.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
King Abdulaziz Medical City
Riyadh, Riyadh Region, 11426, Saudi Arabia
Related Publications (1)
Arabi YM, Alenezi F, Al-Hameed F, Al Humedi HI, Kharaba A, Alhazzani W, Alshahrani MSS, Algethamy H, Maghrabi K, Chalabi J, Ardah HI, Alahmari AM, AlQahtani RM, Ababtain AA, Al-Filfil WAM, Al-Fares AA, Buabbas SF, Bin Humaid F, Brembali MJ, Amer M, Sadat M, Al Tamimi A, AlHumaidan A, Alqahtani M, Al-Dawood A; Saudi Critical Care Trials Group. Diagnosing deep vein thrombosis early in critically ill patients (DETECT) trial: a protocol for a randomised controlled trial. BMJ Open. 2025 Oct 29;15(10):e104468. doi: 10.1136/bmjopen-2025-104468.
PMID: 41161824DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yaseen M Arabi
King Saud bin Abdulaziz University of Health Sciences
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 26, 2021
First Posted
November 9, 2021
Study Start
March 21, 2023
Primary Completion
March 1, 2026
Study Completion (Estimated)
December 1, 2026
Last Updated
September 19, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will share
- Time Frame
- After the publication of the main manuscript (Primary outcome analysis)
- Access Criteria
- Proposal that describes planned analyses must be submitted along with a data sharing agreement
The data supporting this study's findings will be available from the corresponding author upon reasonable request as per the regulations of King Abdullah International Medical Research Center (KAIMRC).