NCT05110248

Brief Summary

Cross-sectional observational study to improve MRI data acquisition techniques by optimising MRI sequences for multiple organs and assessing the repeatability and reproducibility of multiparametric MRI, in healthy volunteers.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Nov 2021

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 26, 2021

Completed
10 days until next milestone

First Posted

Study publicly available on registry

November 5, 2021

Completed
10 days until next milestone

Study Start

First participant enrolled

November 15, 2021

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 15, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 15, 2026

Completed
Last Updated

December 1, 2025

Status Verified

November 1, 2025

Enrollment Period

4.1 years

First QC Date

October 26, 2021

Last Update Submit

November 27, 2025

Conditions

Multiple

Outcome Measures

Primary Outcomes (1)

  • Development of MRI sequences

    Development of sequences which will be used to collect good quality data on multiple organs across different MRI scanners and to ensure that desirable images are obtained within reasonable amount of time.

    2 years from study start

Secondary Outcomes (3)

  • Sequence and parameter validation

    2 years from study start

  • Assessment of MRI metric repeatability

    2 years from study start

  • Assessment of MRI metric reproducibility

    2 years from study start

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Study participants will be adult volunteers aged 18 and over, without a contraindication to magnetic resonance imaging.

You may qualify if:

  • Adults aged 18 years and older
  • Participant is willing and able to give informed consent for participation in the study

You may not qualify if:

  • Any contraindication to magnetic resonance imaging (incl. pregnancy, nonremovable electronic implants including cochlear implants, infusion pumps, and pacemakers, shrapnel injury, severe claustrophobia, allergic reaction to contrast agents)
  • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Gemini One, 5520 John Smith Drive

Oxford, Oxfordshire, OX4 2LL, United Kingdom

RECRUITING

Central Study Contacts

Bryn M Horsington

CONTACT

01865 655343bryn.horsington@perspectum.com

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
CROSS SECTIONAL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 26, 2021

First Posted

November 5, 2021

Study Start

November 15, 2021

Primary Completion

December 15, 2025

Study Completion

January 15, 2026

Last Updated

December 1, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)