Research and Development of Novel Quantitative Magnetic Resonance Imaging (MRI) Techniques in a Single Scan for Multiple Organ Application

NCT05110248 | Recruiting

• 1 other identifier: 21/WS/0066
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

Cross-sectional observational study to improve MRI data acquisition techniques by optimising MRI sequences for multiple organs and assessing the repeatability and reproducibility of multiparametric MRI, in healthy volunteers.

Conditions

Multiple

Outcome Measures

Primary Outcomes (1)

• Development of MRI sequences

  Development of sequences which will be used to collect good quality data on multiple organs across different MRI scanners and to ensure that desirable images are obtained within reasonable amount of time.

  7 years from study start

Secondary Outcomes (5)

• Sequence and parameter validation

  7 years from study start

• Assessment of MRI metric repeatability

  7 years from study start

• Assessment of MRI metric reproducibility

  7 years from study start

• Assessment of participant comfort during scan

  7 years from study start

• Assessment of Standard clinical reference assessment vs MRI

  7 years from study start

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study participants will be adult volunteers aged 18 and over, without a contraindication to magnetic resonance imaging.

You may qualify if:

• Adults aged 18 years and older
• Participant is willing and able to give informed consent for participation in the study
• The participant has a level of English proficiency that allows them to communicate well with the investigator and could comply with study requirements.
• The participant is willing and able to undergo MRI scan.

You may not qualify if:

• Any contraindication to magnetic resonance imaging (incl. pregnancy, nonremovable electronic implants including cochlear implants, infusion pumps, and pacemakers, shrapnel injury, severe claustrophobia, allergic reaction to contrast agents)
• Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study
• The participant may be excluded where body habitus is likely to make MRI or echocardiography/ultrasound uncomfortable or unlikely to yield analysable images, and BMI more than 40-45

Sponsors & Collaborators

• Perspectum: lead

Study Sites (1)

Gemini One, 5520 John Smith Drive

Oxford, Oxfordshire, OX4 2LL, United Kingdom

RECRUITING

Central Study Contacts

Soubera M Rymell, MSc

CONTACT

00447313272482; soubera.rymell@perspectum.com

Rob Suriano, PhD

CONTACT

rob.suriano@perspectum.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 26, 2021
• First Posted: November 5, 2021
• Study Start: November 15, 2021
• Primary Completion (Estimated): March 1, 2031
• Study Completion (Estimated): April 30, 2031
• Last Updated: May 20, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)