Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With STEMI

NCT05107102 | Completed DMC

• 1 other identifier: STEMI-myocardial work
• Study Type: observational
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.

Conditions

ST-Segment Elevated Myocardial Infarction

Keywords

ST-segment elevated myocardial infarction; myocardial work; left ventricular remodeling

Outcome Measures

Primary Outcomes (1)

• Delta-work efficiency by echocardiography

  A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.

  24-72 hours after PCI

Secondary Outcomes (6)

• Global work index by echocardiography

  24-72 hours, 3-month after PCI

• Global constructive work by echocardiography

  24-72 hours, 3-month after PCI

• Global work efficiency by echocardiography

  24-72 hours, 3-month after PCI

• Work index-LAD

  24-72 hours, 3-month after PCI

• Constructive work-LAD

  24-72 hours, 3-month after PCI

Study Arms (2)

patients with LVR(left ventricular remodeling)

patients without LVR(left ventricular remodeling)

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with anterior STEMI who underwent primary PCI \<12 hours after symptom onset were consecutive enrolled in our center.

You may qualify if:

• Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;
• Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.

You may not qualify if:

• significant valvular disease;
• cardiomyopathy; l
• left bundle branch block;
• atrial fibrillation;
• previous myocardial infarction (MI);
• history of cardiac surgery;
• pacemaker implantation.

Sponsors & Collaborators

• RenJi Hospital: lead

Study Sites (1)

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, 200125, China

Location

Related Publications (1)

• Wang W, Zhao H, Wan F, Shen XD, Ding S, Pu J. Inhomogeneous Distribution of Regional Myocardial Work Efficiency Predicts Early Left Ventricular Remodeling After Acute Anterior Myocardial Infarction Treated With Primary Percutaneous Intervention. Front Cardiovasc Med. 2022 Jul 27;9:922567. doi: 10.3389/fcvm.2022.922567. eCollection 2022.

  PMID: 35966524 DERIVED

MeSH Terms

Conditions

Ventricular Remodeling

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Song Ding, MD,PHD

  Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 24, 2021
• First Posted: November 4, 2021
• Study Start: September 10, 2019
• Primary Completion: May 24, 2021
• Study Completion: August 30, 2021
• Last Updated: November 4, 2021

Record last verified: 2021-10

Locations

CN (1)