NCT05106088|Active Not Recruiting
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Sponsor study identifier
observational
50
1 country
1
Study Start
November 22, 2021
Actual (reported)Primary Completion
December 22, 2024
Actual (reported)Study Completion
June 30, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study investigates correlations between humeral head bone marrow characteristics and tendon healing of rotator cuff repairs. The anticipated results would motivate future research aimed to investigate local enrichment or transplantation of connective tissue progenitor cells to augment rotator cuff repair and the pursuit of novel methods of bone marrow screening to preoperatively identify patients with bone marrow characteristics related to rotator cuff repair success or failure.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 14, 2021
Actual (reported)November 3, 2021
Actual (reported)November 22, 2021
Actual (reported)December 22, 2024
Actual (reported)June 30, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Tendon healing
Sugaya score, 1-5 classification from MR imaging
6 months post-operation
Tendon healing
Tendon retraction (mm) from CT imaging
6 months post-operation
Males or females, 18-75 years, with a 1-5 cm full thickness tear of the supraspinatus and/or infraspinatus tendon(s) requiring surgical repair
Cleveland Clinic
Cleveland, Ohio, 44195, United States
At the time of rotator cuff repair, 8 ml of bone marrow will be aspirated from the humeral head for quantitative progenitor cell assays. A core biopsy at the tendon repair footprint will be collected for histologic analysis of bone marrow composition.
Kathleen Derwin, PhD
The Cleveland Clinic
50 participants (actual enrollment reported by the registry).
First Submitted
October 14, 2021
First Posted
November 3, 2021
Study Start
November 22, 2021
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
December 22, 2024
Actual (reported)Study Completion
June 30, 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 23, 2026
Record last verified: 2026-04
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Source: ClinicalTrials.gov.
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