Rehabilitation in Severely Ill Inpatients With COVID-19

NCT05104411 | Completed

• 1 other identifier: B-2108-705-112
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

Inpatient rehabilitation of severe-to-critical COVID-19 patients(A longitudinal, single-center retrospective cohort)

Conditions

COVID-19

Keywords

Rehabilitation; Critical illness; Coronavirus disease 2019 (COVID-19_; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Recovery of function

Outcome Measures

Primary Outcomes (1)

• Change of Functional Ambulation Classification

  0\~5 score. FAC 0(Nonfunctional ambulator), FAC1(Ambulator, dependent on physical assistance - Indicates a patient who requires continuous manual contact to support body weight as well as to maintain balance or to assist coordination), FAC 2(Ambulator, dependent on physical assistance - Indicates a patient who requires intermittent or continuous light touch to assist balance or coordination), FAC3(Ambulator, dependent on supervision), FAC4(Ambulator, independent level surface only), FAC5(Ambulator, independent). Higher score means better outcome.

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

Secondary Outcomes (6)

• Change of Appendicular skeletal muscle mass index (ASMI)

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

• Change of Medical Research Council (MRC) sum score

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

• Change of handgrip strength

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

• Change of number of 1-min sit-to-stand

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

• Change of walking speed

  at baseline, immediately after rehabilitation completion, and 1-month after rehabilitation completion

Interventions

Rehabilitative intervention OTHER

Active rehabilitation programs were done for all patients. Participants were asked to attend exercise program at PT room or bedside. Exercise program was offered once or twice daily on weekdays, by trained kinesiologists. In PT programs, most patients performed strengthening exercise of lower extremities, balance training, sit-up training, sit-to-stand training and gait training for about 30 minutes. Each program was individualized to participants' current physical function. In bedside programs, patients also underwent strengthening exercise and balance training without gait training for about 10 minutes. The duration of exercise program at PT room depends on the patient's condition(upto 1 month).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Severe COVID-19 (WHO ordinal scale 5-7) who participated in the inpatient rehabilitation program

You may qualify if:

• COVID-19 patients who
• underwent intensive care at least two days,
• eventually got negative conversion with two consecutive tests,
• were classified as severe COVID-19 (WHO ordinal scale 5-7) and
• participated in the inpatient rehabilitation program were included.

You may not qualify if:

• COVID-19 patients who died (WHO ordinal scale 8) before discharge were excluded

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam-si, South Korea

Location

Related Publications (1)

• Woo H, Lee S, Lee HS, Chae HJ, Jung J, Song MJ, Lim SY, Lee YJ, Cho YJ, Kim ES, Kim HB, Lim JY, Song KH, Beom J. Comprehensive Rehabilitation in Severely Ill Inpatients With COVID-19: A Cohort Study in a Tertiary Hospital. J Korean Med Sci. 2022 Aug 29;37(34):e262. doi: 10.3346/jkms.2022.37.e262.

  PMID: 36038958 DERIVED

MeSH Terms

Conditions

COVID-19; Critical Illness

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jaewon Beom, MD, PhD

  Department of Rehabilitation Medicine, Seoul National University Bundang Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Associate Professor

Study Record Dates

• First Submitted: October 22, 2021
• First Posted: November 3, 2021
• Study Start: August 14, 2021
• Primary Completion: September 8, 2021
• Study Completion: July 15, 2022
• Last Updated: July 19, 2022

Record last verified: 2022-07

Locations

KR (1)