Impact of Prediabetes on Acute Coronary Syndrome

NCT05102851 | Completed

• 1 other identifier: Soh-Med-21-07-05
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Diabetes mellitus is one of the chronic non-communicable diseases which have emerged as a leading global health problem. According to the International Diabetes Federation Atlas guideline report, currently, there are 352 million adults with impaired glucose tolerance who are at high risk of developing diabetes in the future. In 2017, it was estimated that 425 million people (20-79 years of age) suffered from Diabetes mellitus, and the number is expected to rise to 629 million by 2045. Moreover, Egypt is considered one of the top 10 countries in the world

Conditions

Diabetic Cardiomyopathy

Outcome Measures

Primary Outcomes (2)

• Hba1c

  We consider patients with Hba1c less than 5.7% not diabetic , Patients with Hba1c from 5.7%-6.4% prediabetic and patients with Hba1c 6.5% or more diabetic patients

  Day 1

• CCU admission

  All patients admitted with acute coronary syndrome will be included in the research

  6 months

Study Arms (1)

Patient with acute coronary syndrome

All patients with the acute coronary syndrome were included in the study. Pre-diabetic patient. Non-diabetic patient(Controlled)

Diagnostic Test: Troponin, Lipid profile, HBA1C, Fasting blood glucose level, Creatinine, Body Mass Index

Interventions

Troponin, Lipid profile, HBA1C, Fasting blood glucose level, Creatinine, Body Mass Index DIAGNOSTIC_TEST

Full history: age, sex, smoking, known diabetes, positive family history high serum creatinine, history of prior percutaneous coronary intervention (PCI) or coronary arteries bypass grafting (CABG), or acute coronary syndrome (ACS). hypertension, diet.

Patient with acute coronary syndrome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Statistical presentation and analysis of the present study will be conducted SPSS V.22. Data will be expressed into phases: Ι- Descriptive Mean value(X) and Standard Deviation (SD): for quantitative data. Frequency and percentage for qualitative data. Π- Analytic by t-student test and Chi-square test. P value \>0.05 will be considered statistically non-significant. P value ≤0.05 will be considered statistically significant. P value ≤0.001 will be considered statistically highly significant. Variance: Correlation of MPV with other parameters was performed by Pearson correlation test (r value as the coefficient).

You may qualify if:

• All patients with acute coronary syndrome
• Diabetic patients and will be subdivided into controlled and uncontrolled Pre-diabetic patients.
• Non-diabetic patient(Controlled)

You may not qualify if:

• Patient under 18 years old
• Pregnancy
• Chronic kidney disease
• Familiar hyperlipidemia.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82524, Egypt

Location

MeSH Terms

Conditions

Diabetic Cardiomyopathies

Interventions

Body Mass Index

Condition Hierarchy (Ancestors)

Cardiomyopathies; Heart Diseases; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Anthropometry; Investigative Techniques; Physiological Phenomena; Biometry; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Amal K. Ahmed, Ass. Prof.

  Sohag University

  STUDY DIRECTOR

• Hany A. Muhammed Khalil, Lecturer

  Sohag University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor at Internal Medicine department, Sohag University Hospital

Study Record Dates

• First Submitted: August 18, 2021
• First Posted: November 2, 2021
• Study Start: August 1, 2021
• Primary Completion: August 1, 2022
• Study Completion: August 23, 2022
• Last Updated: August 31, 2022

Record last verified: 2021-07

Locations

EG (1)