Establishment of Risk Indicators and Early Warning System in Infection Patients

NCT05099120 | Unknown

• 1 other identifier: Jingwen Wang
• Study Type: observational
• Target: 16,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Serious infections refer to life-threatening infections with a morbidity and mortality rate of up to 50%, and are the main cause of death in critically ill patients, mainly including systemic inflammatory response syndrome, sepsis, infectious shock, or systemic multiple organ dysfunction syndrome. Patients with severe infections have rapid disease development, which can cause disorders of cellular circulation and metabolism and impairment of multi-organ function in the early stage, mostly accompanied by clinical complications, and despite the progress of medical technology and the popularization of antibiotic application, the mortality and disability rate is high, which is a hot spot of clinical research today. Patients with severe infections are exposed to a wide range of medical risk factors, including patient factors (advanced age, frailty, malnutrition, long hospital stay, prolonged bed rest), disease factors (immune deficiency, malignancy, diabetes, renal failure, liver failure), drug factors (long-term use of steroid hormones, chemotherapeutic drugs, NSAIDs, etc.), interventional factors (central venous catheter, recent invasive surgery, hemodialysis, endotracheal intubation or mechanical ventilation, etc.), which bring great challenges to clinical treatment. Therefore, early identification of risk indicators for deterioration of infected patients provides a strategic basis for the medical team to take early warning measures to prevent deterioration and poor prognosis, and to reduce the risk of deterioration of patients, which is also the key to reduce the risk of death of infected patients.

Conditions

Infections

Outcome Measures

Primary Outcomes (1)

• Among patients with infections admitted to the hospital

  primary outcome measure were defined as the death.

  30 days of hospitalization

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We integrated pooled individual patient data of infected patients treated at a single center in China from 1 January 2010 until 31 July 2021.

You may qualify if:

• Patients diagnosed with infection

You may not qualify if:

• Case information is incomplete
• Do not accept follow-up

Sponsors & Collaborators

• Xijing Hospital: lead

MeSH Terms

Conditions

Infections

Study Officials

• Jingwen Wang

  The First Affiliated Hospital of Air Force Medical University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 11, 2021
• First Posted: October 29, 2021
• Study Start: January 1, 2010
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: February 28, 2022

Record last verified: 2021-08