Health Benefits of Whole-body Vibration

NCT05097885 | Recruiting

• 1 other identifier: 1818010
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.

Conditions

Whole-body Vibration

Outcome Measures

Primary Outcomes (6)

• Change in VO2 Peak

  change from baseline relative (mL/kg/min) peak oxygen consumption (VO2) during maximal exercise test at 12 weeks

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

• Change in Flow-Mediated Dilation (FMD)

  change from baseline brachial artery flow mediated dilation at 12 weeks.

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

• Change in Skeletal Muscle Mitochondrial Function

  change from baseline skeletal muscle mitochondrial function at 12 weeks. Measured using Near Infrared Spectroscopy (NIRS). Values are an index of phosphocreatine recovery expressed as a rate constant (min-1)

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

• Change in Pulse Wave Velocity (PWV)

  Change from baseline PWV at 12 weeks. Measured by Shygmocor Xcel in m/s.

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

• Change in Post Occlusive Reactive Hyperemia (PORH)

  Change from baseline PORH at 12 weeks. Measured by Laser Speckle Contrast Imager (Moor FLPI).

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

• Change in IL-6

  change from baseline concentrations of Interleukin 6 (IL-6) obtained via blood draw at 12 weeks.

  pre-treatment baseline and following 12 weeks sub-acute whole-body vibration

Study Arms (1)

Sub Acute (12 week) Whole Body Training

EXPERIMENTAL

Other: Sub Acute Whole Body Vibration Training

Interventions

Sub Acute Whole Body Vibration Training OTHER

Participants will be given a personal vibration plate to take home with them for training which will last for 12 weeks. For the first four weeks, participants will be asked to complete 10 minutes of WBV per day (1 minute on and up to 1 minute of rest), at least 3-4 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 14 minutes and/or reduce the duration of rest. Beginning at week 9, participants will be asked to increase WBV time to up to 20 minutes and/or reduce the duration of rest.

Sub Acute (12 week) Whole Body Training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women (\> 18 yrs old)
• All races

You may not qualify if:

• \<18 years old
• Clinical diagnosis of hepatic, cardiovascular, or renal disease
• Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
• Pregnancy
• Direct vasoactive medications (i.e. nitrates)

Sponsors & Collaborators

• Augusta University: lead

Study Sites (1)

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology

Augusta, Georgia, 30912, United States

RECRUITING

Central Study Contacts

Jacob Looney, MS

CONTACT

7067215483; jlooney@augusta.edu

Ryan Harris, PhD

CONTACT

7067215998; ryharris@augusta.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 15, 2021
• First Posted: October 28, 2021
• Study Start: February 28, 2022
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2028
• Last Updated: January 28, 2025

Record last verified: 2025-01

Locations

US (1)