Acute Supplementation With Beta-Alanine Improves Performance in Aerobic-anaerobic Transition Zones in Endurance Athletes

NCT05096793 | Completed

• 1 other identifier: 04102021
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The use of beta-alanine (BA) to increase physical performance is widely documented. However, the acute effect of this amino acid on maximal tests in the aerobic-anaerobic transition zone is still uncertain. The objective of this study was to determine the acute effect of low and high-dose BA trials on maximal aerobic speed (MAS) in endurance athletes. We hypothesized that high doses of BA have a greater effect than low doses, both compared to baseline. Twelve male endurance athletes volunteered for the study. The experimental design applied was randomized cross-over, double-blind. Treatment included three 6-minute run tests (6-MRT), the first as a baseline, then randomized 6-MRT with low (30 mg·kg-1) and high (45 mg·kg-1) dose BA trials. The 6-MRTs were separated by 72 hours. The main variable of the study was the distance (m) performed in the 6-MRT. Differences between tests were established through ANOVA and Tukey's multiple comparison tests (p \< 0.05).

Conditions

Beta-alanine

Keywords

beta-alanine; ergogenic aid; physical performance; aerobic-anaerobic transition zones; maximal aerobic speed

Outcome Measures

Primary Outcomes (1)

• 6-minute race test (meters)

  The test was performed on an official 400 m athletic track simultaneously every measurement day (09:00 - 11:00 a.m.) and under similar climatic conditions (temperature = 16 - 18° C and relative humidity = 70 - 80%). Also, to simulate the reality of the competition, the 6-MRT was performed in subgroups of three participants. These subgroups were maintained throughout the intervention, modifying only the dose of BA ingested.

  at the end of the 6 minute test

Secondary Outcomes (2)

• Lactate

  at the end of the 6 minute test

• Heart Rate

  at the end of the 6 minute test

Study Arms (3)

Control

EXPERIMENTAL

the distance in the 6-MRT compared to baseline

Dietary Supplement: beta alanine

Low doses

EXPERIMENTAL

the distance in the 6-MRT compared to baseline

Dietary Supplement: beta alanine

High doses

EXPERIMENTAL

the distance in the 6-MRT compared to baseline

Dietary Supplement: beta alanine

Interventions

beta alanine DIETARY_SUPPLEMENT

On day 1, all participants completed the 6-MRT corresponding to baseline. Then, on days 2 and 3, each participant performed the 6-MRT with 30 mg·kg-1 and 45 mg·kg-1 of BA (low and high-dose trials, respectively). BA was purchased in powder format from a factory specializing in sports supplements. BA was colorless when diluted in water and had a characteristic taste. This format of BA (powder) allowed personalized dosing for each participant. The research team performed the personalized dosing before the application of the treatment. Between the evaluation days, there was 72 hours difference. The 30 mg·kg-1 or 45 mg·kg-1 BA administration was done with a double-blind method. Thus, on day 2, 50% of the sample performed the 6-MRT supplemented with 30 mg·kg-1 BA, while the other 50% performed the 6-MRT with 45 mg·kg-1 BA. On day 3, those participants who completed the 6-MRT with 30 mg·kg-1 BA now performed with 45 mg·kg-1 BA and vice versa.

Control; High doses; Low doses

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Sponsors & Collaborators

• University of Americas: lead

Study Sites (1)

Uamericas

Viña del Mar, 0, Chile

Location

Related Publications (28)

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MeSH Terms

Interventions

beta-Alanine

Intervention Hierarchy (Ancestors)

Alanine; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Hernán Cañon, Ph.D.

  University of Americas

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: The experimental design applied was randomized cross-over and double-blind

Study Record Dates

• First Submitted: October 4, 2021
• First Posted: October 27, 2021
• Study Start: May 3, 2021
• Primary Completion: May 9, 2021
• Study Completion: August 31, 2021
• Last Updated: November 3, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)