Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)

NCT05094349 | Completed

• 1 other identifier: SAH-CIP (29BRC19.0311)
• Study Type: observational
• Target: 224
• Locations: 1 country
• Sites: 1

Brief Summary

Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI). Infection and more precisely pneumonia have been associated with poor outcome in SAH. However, the interaction between the two pathologic events remains unclear. Therefore, we hypothesized that DCI may be associated to pneumonia in SAH patients. Thus the aim of the study is to analyze the association between delayed cerebral infarction and pneumonia in patients with SAH. Retrospective, observational, monocentric cohort study, including patient admitted in Neurosurgical Intensive Care Unit or Surgical Intensive Care Unit in the University Hospital of Brest (France) for non-traumatic SAH. Primary outcome is diagnosis of DCI on CT scan or MRI 3 months after SAH. Multivariate analysis is used to identify factors independently associated with DCI. We plan to include between 200 and 250 patients in the analysis.

Conditions

Subarachnoid Hemorrhage; Pneumonia, Bacterial

Keywords

Subarachnoid hemorrhage; pneumonia; delayed cerebral ischemia; vasospasm; delayed cerebral infarction

Outcome Measures

Primary Outcomes (1)

• delayed cerebral infarction

  infarction on CT or MRI not related to initial bleeding

  3 months from subarachnoid hemorrhage

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patient admitted to ICU for subarachnoid hemorrhage (SAH). in our institution every patient diagnosed with non traumatic SAH are admitted for at least 24 hours in ICU.

You may qualify if:

• admitted in ICU in Brest University Hospital
• for non traumatic subarachnoid hemorrhage
• between july 2015 and december 2018

You may not qualify if:

• continuation of care out of Brest University Hospital after initial ICU stay
• refusal to participate

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

CHRU de Brest

Brest, 29609, France

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Pneumonia, Bacterial; Pneumonia

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 14, 2021
• First Posted: October 26, 2021
• Study Start: February 20, 2020
• Primary Completion: July 15, 2020
• Study Completion: July 15, 2020
• Last Updated: October 26, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be available beginning 2 years and ending five years following the end of study
• Access Criteria: Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.

Locations

FR (1)