Physical Activity, Air Pollution, and High Blood Pressure

NCT05092672 | Completed

• 1 other identifier: H21-01487
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are investigating the effects of traffic-related air pollution (TRAP) on the cardiovascular and pulmonary response to exercise in patients with hypertension using a real world randomized, crossover study design. Participants will be exposed to 2 conditions: a low TRAP environment and a high TRAP environment. Each exposure will consist of 30 min of moderate-intensity exercise. Cardiovascular and pulmonary health outcomes will be measured before, during, and up to 24 hours following exposures. A minimum washout period of 1 week will be used to minimize carryover effects.

Conditions

Essential Hypertension

Keywords

Traffic-related air pollution; Physical activity; Exercise; Blood pressure; Heart rate variability; Arterial stiffness; Microvascular responsiveness; Muscle oxygen saturation; Lung function

Outcome Measures

Primary Outcomes (1)

• Change from Baseline Blood Pressure at 2 Hours Post-Exposure

  MAP, SBP, and DBP

  Baseline and 2 hours post-exposure

Secondary Outcomes (9)

• 24-Hour Blood Pressure

  24 hours post-exposure

• Heart Rate Variability

  Baseline and up to 24 hours post-exposure

• Change from Baseline Arterial Stiffness at 2 Hours Post-Exposure

  Baseline and 2 hours post-exposure

• Change from Baseline Microvascular Responsiveness at 2 Hours Post-Exposure

  Baseline and 2 hours post-exposure

• Muscle Oxygen Saturation

  Continuously throughout the 30 minute exercise bouts (during exposure)

Study Arms (2)

High traffic-related air pollution first

EXPERIMENTAL

Participants will exercise in an environment with high levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with low levels of traffic-related air pollution.

Behavioral: Exercise

Low traffic-related air pollution

EXPERIMENTAL

Participants will exercise in an environment with low levels of traffic-related air pollution first. Afterwards, participants will complete the same exercise in an environment with high levels of traffic-related air pollution.

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

Participants will engage in moderate-intensity (40-59% HRR) exercise for 30 min

High traffic-related air pollution first; Low traffic-related air pollution

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 40-70 years of age
• Previously diagnosed with elevated blood pressure or hypertension by a physician

You may not qualify if:

• Current or ex-smokers (abstinent for less than one year)
• Lives with an individual who currently smokes cigarettes, e-cigarettes (i.e., vaping), or cannabis
• Hormone replacement therapy use
• Currently on beta-blocker or angiotensin receptor blocker (ARB) therapy
• Currently using over the counter drugs or supplements that may alter cardiovascular measures (as per the principal investigator's discretion)
• Prior diagnosis of any other existing cardiovascular or pulmonary diseases and/or conditions (other than hypertension)
• Musculoskeletal injury or lower limb limitation preventing safe engagement in moderate-intensity exercise

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia

Vancouver, British Columbia, V6T 1Z3, Canada

Location

MeSH Terms

Conditions

Essential Hypertension; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Hypertension; Vascular Diseases; Cardiovascular Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Michael Koehle, MD, PhD

  Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Crossover Assignment

Study Record Dates

• First Submitted: September 28, 2021
• First Posted: October 25, 2021
• Study Start: November 15, 2021
• Primary Completion: August 1, 2024
• Study Completion: August 1, 2024
• Last Updated: August 12, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)