Transdiagnostic Internet Intervention to Improve Mental Health Among University Students

NCT05085756 | Active Not Recruiting

• 1 other identifier: 2021-03599
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study offers transdiagnostic CBT-based treatment for symptoms of depression and anxiety to university students who have previously responded to the WHO-WMH-ICS survey.

Conditions

Psychological Disorder

Outcome Measures

Primary Outcomes (2)

• PHQ-9 for depression

  9 items measuring depressive symptoms

  last 2 weeks

• GAD-7 for anxiety

  7 items measuring anxiety symptoms

  last 2 weeks

Study Arms (3)

Guided treatment

ACTIVE COMPARATOR

8-week transdiagnostic CBT with written guidance from M.Sc-level students under supervision.

Behavioral: Puma

Unguided treatment

ACTIVE COMPARATOR

8-week transdiagnostic CBT without guidance.

Behavioral: Puma

Waitlist

OTHER

8-week transdiagnostic CBT without guidance, made available 6 months after recruitment.

Behavioral: Puma

Interventions

Puma BEHAVIORAL

One psychoeducation module followed by two transdiagnostic modules tailored to primary depression or anxiety symptoms, followed by three participant-choice modules, and ending with two transdiagnostic modules.

Guided treatment; Unguided treatment; Waitlist

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• PHQ-9 cutoff for mild depression
• GAD-7 cutoff for mild anxiety

You may not qualify if:

• Suicidal ideation or plans
• Severe levels of mental ill-health

Sponsors & Collaborators

• Uppsala University: lead
• Linkoeping University: collaborator
• Malmö University: collaborator
• Stockholm University: collaborator
• Karolinska Institutet: collaborator

Study Sites (1)

Uppsala University

Uppsala, 75105, Sweden

Location

Related Publications (2)

• Andersson C, Bendtsen M, Lindfors P, Molander O, Lindner P, Topooco N, Engstrom K, Berman AH. Does the management of personal integrity information lead to differing participation rates and response patterns in mental health surveys with young adults? A three-armed methodological experiment. Int J Methods Psychiatr Res. 2021 Dec;30(4):e1891. doi: 10.1002/mpr.1891. Epub 2021 Aug 21.

  PMID: 34418224 BACKGROUND

• Berman AH, Topooco N, Lindfors P, Bendtsen M, Lindner P, Molander O, Kraepelien M, Sundstrom C, Talebizadeh N, Engstrom K, Vlaescu G, Andersson G, Andersson C. Transdiagnostic and tailored internet intervention to improve mental health among university students: Research protocol for a randomized controlled trial. Trials. 2024 Mar 1;25(1):158. doi: 10.1186/s13063-024-07986-1.

  PMID: 38429834 BACKGROUND

MeSH Terms

Conditions

Mental Disorders

Interventions

bbc3 protein, zebrafish

Study Officials

• Anne H Berman, PhD

  Dept of Psychology, Uppsala University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 6, 2021
• First Posted: October 20, 2021
• Study Start: March 14, 2022
• Primary Completion: December 30, 2025
• Study Completion (Estimated): June 30, 2027
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)