NCT05084690

Brief Summary

Cross-education describes the transfer of motor performance to the opposite limb following unilateral training and is primarily explained by adaptations within the brain. The mirror training hypothesis suggests that illusionary mirror visual feedback may augment the cross-education of strength to the untrained, contralateral limb. The purpose of this project is to examine how the use of illusionary mirror visual feedback shapes the neuromuscular adaptations that occur for both limbs during unilateral (single-limb) strength training. Our hypothesis is that mirror training will augment the level of cross-education for the untrained arm.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jul 2021

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 19, 2021

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

October 7, 2021

Completed
13 days until next milestone

First Posted

Study publicly available on registry

October 20, 2021

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 19, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 19, 2023

Completed
Last Updated

October 20, 2021

Status Verified

October 1, 2021

Enrollment Period

2.1 years

First QC Date

October 7, 2021

Last Update Submit

October 7, 2021

Conditions

Exercise TherapyWeight Lifting

Keywords

Strength trainingMirror visual feedback

Outcome Measures

Primary Outcomes (5)

  • Change in dynamic muscle strength for the trained and untrained arm

    Dynamic 1-repetition maximum (lbs)

    Baseline (week 0) post-training (week 5)

  • Change in isometric muscle strength for the trained and untrained arm

    Isometric maximal voluntary contraction

    Baseline (week 0) post-training (week 5)

  • Change in lean mass for the trained and untrained arm

    DEXA (g)

    Baseline (week 0), mid-training (week 2), post-training (week 5)

  • Change in muscle thickness for the trained and untrained arm

    Ultrasound muscle thickness (cm)

    Baseline (week 0), mid-training (week 2), post-training (week 5)

  • Change in muscle activation for the trained and untrained arm

    Electromyographic amplitude (volts)

    Baseline (week 0) post-training (week 5)

Study Arms (2)

Resistance training control group

ACTIVE COMPARATOR

The resistance training control group will perform unilateral resistance training on their dominant arm. The training will be performed twice per week for four weeks totaling eight training sessions.

Other: Unilateral resistance training

Resistance training with mirror illusion group

EXPERIMENTAL

The resistance training with mirror illusion group will perform unilateral resistance training on their dominant arm. During training, they will view a mirror illusion of their exercising arm over their opposite, non-exercising arm. The training will be performed twice per week for four weeks totaling eight training sessions.

Other: Unilateral resistance trainingOther: Illusionary mirror visual feedback

Interventions

Unilateral resistance trainingOTHER

Unilateral resistance training of the elbow flexors

Resistance training control groupResistance training with mirror illusion group
Illusionary mirror visual feedbackOTHER

Modified Ramachandran's mirror box

Resistance training with mirror illusion group

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • right-hand dominance
  • no previous strength training of upper body last 3 months
  • no injuries or recent surgeries of the upper limbs
  • willingness to adhere to the strength training requirements of the study

You may not qualify if:

  • current use of hormone replacement therapy
  • pregnancy/breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

TCU Neuromuscular Physiology Laboratory

Fort Worth, Texas, 76126, United States

Location

TCU RIC

Fort Worth, Texas, 76126, United States

Location

Study Officials

  • Joshua C Carr

    Texas Christian University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Model Details: Randomized, two arm parallel experimental and control groups
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 7, 2021

First Posted

October 20, 2021

Study Start

July 19, 2021

Primary Completion

August 19, 2023

Study Completion

August 19, 2023

Last Updated

October 20, 2021

Record last verified: 2021-10

Locations

US(2)