Cannabis and Aging
Cannabis Use and Risk of Falling in Older Adults: an Observation Study
1 other identifier
observational
60
1 country
1
Brief Summary
With increased availability and use of cannabis by older adults aged ≥ 50 years, a rigorous evaluation of the benefits and risks of cannabis use in these individuals is necessary. Our proposed project will investigate whether older adults who initiate cannabis use after the age of 50 are at an increased risk of fall and what are the underlying mechanisms. We will measure motor and cognitive function in older cannabis users and nonusers and we will use positron emission tomography to determine brain activity and how it is associated with fall risk.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2020
CompletedFirst Submitted
Initial submission to the registry
October 5, 2021
CompletedFirst Posted
Study publicly available on registry
October 19, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2021
CompletedMay 24, 2022
May 1, 2022
1.8 years
October 5, 2021
May 23, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Fall Risk
The following equation for the prediction of falls will be used: Likelihood of falling (%) = (exp (-7.519 + 0.026(reaction time) - 0.071(ABC1) - 2.139(Berg 14))) / (1 + exp (-7.519 + 0.026(reaction time) - 0.071(ABC1) - 2.139(Berg 14)) ×100)
Through study completion, on average 1 year
Brain activity PET Imaging
To investigate cerebral glucose uptake in older chronic cannabis users and non-users
Through study completion, on average 1 year
Study Arms (2)
Cannabis Group
A total of 30 older (age 50-80 years) men and women who are using cannabis.
Control Group
A total of 30 older (age 50-80 years) men and women who are not using cannabis.
Eligibility Criteria
A total of 30 older (age 50-80 years) men and women who are using cannabis and 30 controls who are non-users, will be recruited.
You may qualify if:
- years
- Healthy enough to complete the protocol based on information obtained from a clinical exam and past medical history, such as cardiovascular diseases.
- Comprehension of the protocol as indicated by an ability to respond to questions about the study after reading the consent form.
- Able to use and be contacted by telephone.
- Able to speak, read, and understand English, and complete a questionnaire in English
You may not qualify if:
- Presence of pacemakers, aneurysm clips, artificial heart valves, metallic prostheses
- Pregnancy
- History of significant traumatic brain injury
- Unable to lie flat for the study imaging
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Thorsten Rudrofflead
Study Sites (1)
Department of Health and Human Physiology
Iowa City, Iowa, 52242, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
October 5, 2021
First Posted
October 19, 2021
Study Start
February 1, 2020
Primary Completion
November 1, 2021
Study Completion
November 1, 2021
Last Updated
May 24, 2022
Record last verified: 2022-05
Data Sharing
- IPD Sharing
- Will not share