Infantile Hemangioma With Minimal or Arrested Growth : Epidemiology, Clinical Characteristics and Evolution

NCT05080868 | Completed DMC

• 1 other identifier: 2019PI221
• Study Type: observational
• Target: 224
• Locations: 1 country
• Sites: 1

Brief Summary

Infantile hemangioma (IH) is the most common vascular tumor of infancy, characterized by its clinical history. Absent at birth or present under the form of a premonitory mark, they display a rapid proliferative phase starting in the first weeks of life. Then, after a plateau phase, they slowly involute. However, a subtype of IH named "abortive", "minimal or arrested growth", "reticular" or "telangiectatic" hemangioma differs from typical IH because it doesn't have a proliferative component, or only a minimal one. This subtype of hemangioma has been recently described and data are lacking regarding its proportion among infantile hemangioma and its differences with "classic" infantile hemangioma. The aim of this study is to estimate the proportion of abortive hemangioma among infantile hemangioma. Also, the investigators aim to compare the clinical characteristics of "classic" infantile hemangiomas and abortive hemangiomas. Lastly, investigators wished to study the evolution of abortive hemangioma.

Conditions

Hemangioma, Capillary

Outcome Measures

Primary Outcomes (1)

• Proportion of abortive hemangioma among infantile hemangioma

  Proportion of abortive hemangioma among infantile hemangioma

  baseline

Secondary Outcomes (13)

• To compare the epidemiological characteristics between infantile hemangioma and abortive hemangioma : sex

  baseline

• To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : prematurity

  baseline

• To compare the epidemiological characteristics between infantile hemangiomas and abortive hemangiomas : birthweight

  baseline

• To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : localization

  baseline

• To compare the clinical characteristics between infantile hemangiomas and abortive hemangiomas : treatment

  baseline

Study Arms (2)

Infantile hemangioma with minimal or arrested growth

Epidemiological and clinical characteristics of infantile hemangioma with minimal or arrested growth.

Classic infantile hemangioma

Epidemiological and clinical characteristics of classic infantile hemangioma.

Eligibility Criteria

• Age: 1 Day - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

\- Children between 0 and 18 years old followed in the dermatology department of CHRU de Nancy between January 2014 and December 2020 presenting with one or more infantile hemangioma

You may qualify if:

• Children between 0 and 18 years old
• Followed in the dermatology department of CHRU de Nancy between January 2014 and December 2020
• Presenting with one or more infantile hemangioma

You may not qualify if:

• \- Those whoes guardian does not want his data to be collected in this study

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

CHRU de Nancy

Nancy, Grand Est, 54000, France

Location

MeSH Terms

Conditions

Hemangioma, Capillary

Condition Hierarchy (Ancestors)

Hemangioma; Neoplasms, Vascular Tissue; Neoplasms by Histologic Type; Neoplasms

Study Officials

• BURSZTEJN Anne-Claire, MD, PhD

  Central Hospital, Nancy, France

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2021
• First Posted: October 18, 2021
• Study Start: March 23, 2021
• Primary Completion: May 30, 2021
• Study Completion: August 15, 2021
• Last Updated: October 18, 2021

Record last verified: 2021-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)