Safe and Timely Antithrombotic Removal (STAR) Registry
1 other identifier
observational
1,000
6 countries
30
Brief Summary
This registry will capture real-world clinical use patterns and associated clinical outcomes with the use of CytoSorb for the removal of antithrombotic agents.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2021
Longer than P75 for all trials
30 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 9, 2021
CompletedStudy Start
First participant enrolled
September 30, 2021
CompletedFirst Posted
Study publicly available on registry
October 14, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2025
CompletedJuly 16, 2025
July 1, 2025
4 years
September 9, 2021
July 15, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Bleeding complications including requirements for transfusions and other blood products
Assessed until postoperative day (POD) 3, date of ICU discharge, or date of death, whatever comes first; on average 3 days
Interventions
Sorbent hemoperfusion system
Eligibility Criteria
All patients undergoing invasive management, including surgery, who receive CytoSorb therapy for antithrombotic removal as part of their routine clinical care can be included in this registry
You may qualify if:
- CytoSorb utilization for antithrombotic removal
- Informed consent for prospective registry participation
You may not qualify if:
- Use of CytoSorb for purpose other than antithrombotic removal
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (30)
Universitätsklinikum Graz
Graz, Austria
Medizinische Universität Innsbruck
Innsbruck, Austria
Klinikum Klagenfurt am Wörthersee
Klagenfurt, Austria
Medical University of Vienna
Vienna, Austria
Centre Hospitalier Universitaire de Liège
Liège, Belgium, Belgium
OLV ziekenhuis Aalst VZW
Aalst, Belgium
Cliniques Universitaires Saint-Luc
Brussels, Belgium
University Hospital Ghent
Ghent, Belgium
Evangelisches Herzzentrum Coswig
Coswig, Germany
Herzchirurgische Klinik Erlangen
Erlangen, Germany
Universitätsklinikum Essen
Essen, Germany
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Universitätsklinikum Heidelberg - Klinik für Herzchirurgie
Heidelberg, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Herz- und Gefäßchirurgie
Kiel, Germany
Herzzentrum Leipzig and Helios Health Institute GmbH Leipzig
Leipzig, Germany
Artemed Klinikum München Süd GmbH & Co. KG
Munich, Germany
LMU Klinikum Großhadern
Munich, Germany
Deutsches Herzzentrum München
München, Germany
Klinikum Nürnberg
Nuremberg, Germany
Klinikum Oldenburg AöR
Oldenburg, Germany
Krankenhaus der Barmherzigen Brüder Trier
Trier, Germany
Universitätsklinikum Ulm
Ulm, Germany
Skåne University Hospital Lund
Lund, Sweden
Hôpitaux Universitaires Genève
Geneva, Switzerland
Stadtspital Zürich Clinic for Cardiac Surgery
Zurich, 8063, Switzerland
Universitätsspital Zürich
Zurich, Switzerland
Blackpool Teaching Hospitals NHS Foundation Trust/ Blackpool Victoria Hospital
Blackpool, United Kingdom
Royal Brompton & Harefield Clinical Group (part of Guy's and St Thomas' NHS Foundation TRUST)
London, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
Related Publications (4)
Schmoeckel M, Thielmann M, Hassan K, Geidel S, Schmitto J, Meyer AL, Vitanova K, Liebold A, Marczin N, Bernardi MH, Tandler R, Lindstedt S, Matejic-Spasic M, Wendt D, Deliargyris EN, Storey RF. Intraoperative haemoadsorption for antithrombotic drug removal during cardiac surgery: initial report of the international safe and timely antithrombotic removal (STAR) registry. J Thromb Thrombolysis. 2024 Aug;57(6):888-897. doi: 10.1007/s11239-024-02996-x. Epub 2024 May 6.
PMID: 38709456BACKGROUNDSchmitto J, De Somer F, Thielmann M, Marczin N, Ruhparwar A, Meyer AL, Hagl C, Matejic-Spasic M, Wendt D, Fan W, Deliargyris EN, Storey RF, Schmoeckel M. Intraoperative antithrombotic drug removal during heart transplantation: A case series from the International Safe and Timely Antithrombotic Removal (STAR) registry. JHLT Open. 2025 Aug 20;10:100369. doi: 10.1016/j.jhlto.2025.100369. eCollection 2025 Nov.
PMID: 40933270DERIVEDStorey RF, Hassan K, Meyer AL, Eberle T, deNeve N, Thielmann M, Bernardi MH, Marczin N, Guenther U, Panholzer B, Maechler H, Hunter S, Matejic-Spasic M, Wendt D, Deliargyris EN, Schmoeckel M. Early CABG with intraoperative hemoadsorption in patients on ticagrelor: Real world data from the international Safe and Timely Antithrombotic Removal (STAR) registry. Cardiovasc Revasc Med. 2025 Feb 28:S1553-8389(25)00065-X. doi: 10.1016/j.carrev.2025.02.015. Online ahead of print.
PMID: 40044567DERIVEDSchmoeckel M, Thielmann M, Vitanova K, Eberle T, Marczin N, Hassan K, Liebold A, Lindstedt S, Machler G, Matejic-Spasic M, Wendt D, Deliargyris EN, Storey RF. Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic Removal (STAR) registry. J Cardiothorac Surg. 2025 Jan 20;20(1):74. doi: 10.1186/s13019-024-03326-1.
PMID: 39833891DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michael Schmoeckel, Prof, MD
LMU Klinikum Großhadern
- PRINCIPAL INVESTIGATOR
Robert Storey, Prof, BSc
University of Sheffield
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 9, 2021
First Posted
October 14, 2021
Study Start
September 30, 2021
Primary Completion
September 30, 2025
Study Completion
September 30, 2025
Last Updated
July 16, 2025
Record last verified: 2025-07
Data Sharing
- IPD Sharing
- Will not share