Air Pollution and Health of COPD Patients
Effect of Air Pollution on Prognosis of Patients With Chronic Obstructive Pulmonary Disease and Its Underlying Biological Mechanism
1 other identifier
observational
110
1 country
1
Brief Summary
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2021
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 16, 2021
CompletedStudy Start
First participant enrolled
October 12, 2021
CompletedFirst Posted
Study publicly available on registry
October 13, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2024
CompletedJune 3, 2025
May 1, 2025
2.7 years
September 16, 2021
May 28, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Lung function
Lung function test was conducted.
Nine months
Secondary Outcomes (7)
COPD Assessment Test scores
Nine months
Modified British Medical Research Council (mMRC) Questionnaire score
Nine months
ST. George's Respiratory Questionnaire scores
Nine months
Blood pressure
Nine months
Respiratory inflammation
Nine months
- +2 more secondary outcomes
Interventions
Particulate matter and gaseous pollutants
Eligibility Criteria
Stable COPD patients aged 40-80 in Beijing, China
You may qualify if:
- doctor-diagnosed stable COPD patients
- aged 40 to 80 years
- lived in Beijing for over one year before being recruited
- Agree to participate and sign the informed consent form.
You may not qualify if:
- Patients with a history of acute exacerbation in the last 1 month
- Patients with other respiratory diseases such as bronchiectasis and asthma.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peking University
Beijing, China, 100191, China
Related Publications (1)
Zhang W, Chen B, Shima M, Zhao C, Guo L, Yoda Y, Li S, Wu S, Chen Y, Guo X, Deng F. PM2.5 as a risk factor for sleep oxygen desaturation in COPD: identifying susceptible individuals by smoking and inflammatory phenotypes. Thorax. 2025 Sep 15;80(10):683-692. doi: 10.1136/thorax-2025-223140.
PMID: 40541407DERIVED
Biospecimen
Morning urine, exhaled Breath Condensate, saliva and venous blood
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Furong Deng, Doctor
Peking University
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Deputy Director of Department of Occupational and Environmental Health Sciences
Study Record Dates
First Submitted
September 16, 2021
First Posted
October 13, 2021
Study Start
October 12, 2021
Primary Completion
June 30, 2024
Study Completion
December 31, 2024
Last Updated
June 3, 2025
Record last verified: 2025-05
Data Sharing
- IPD Sharing
- Will not share