Electrochemistry Measurement of Skin Hydration Parameters

NCT05071456 | Unknown

• 1 other identifier: APHP210446
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

To date measuring the effect of dermocosmetic products on the main identified factors of aging and alteration of the skin barrier is based on invasive and expensive experiments. Electrochemistry enables to measure a specific signal for a substance of interest e.g. Vitamin C using an surface contact with an electrode. Therefore, this study will evaluate the reliability and feasibility of measurements of skin's hydration parameters such as NMF and squalene using electrochemistry. These study will be made on three groups of individuals with different skin types: dry skin i.e. atopic dermatitis patients, oily skin i.e. acne skin and a control group of individual without facial dermatosis. Collects of parameters of interest will be made by using patch using electrochemistry (contact with an electrode and potentiostat to detect an electric signal) . It is a simple method that relies on a sensor / electrode pair that allows a study of the surface molecules of the skin. Application in the measurement of vitamin C in food products has already been validated. On a second hand, a collect by chromatography of the parameters of interest will be carried out in order to compare the new method with the reference method. This procedure has been developed via a procedure including collecting surface parameters using a patch an developping special electrodes and miniaturized detecting signal tool (potentiostat)

Conditions

Atopic Dermatitis; Acne; Skin Electrochemistry

Keywords

Electrochemistry; Squalene; NMF; Skin

Outcome Measures

Primary Outcomes (1)

• Feasibility of collecting an electrochemical measure of skin hydration parameter (natural moisturizer factor electric signal) at two different sites of the face at T0 using patch and electrode

  Feasibility of collecting an electrochemical measure of skin hydration parameter (natural moisturizer factor electric signal) at two different sites of the face at T0 using patch and electrode. Signal detection (mVolt) or not using a patch to collect skin surface parameter applied on an electrode to collect and electric signal.

  Day 0 or Day 1

Secondary Outcomes (3)

• Validation of the measure process for different skin type e.g: dry, oily, normal

  Day 0 or Day 1

• Determine the correlation between electrochemistry measures or skin hydration (level of electrical signal mvolt ) and reference method: corneometry or chromatography.

  Day 0 or Day 1

• Describe individuals' habits or daily routine for skin care using a questionnairemethodology (corneometry or chromatography)

  Day 0 or Day 1

Study Arms (3)

Atopic dermatitis patients

EXPERIMENTAL

Other: Collects of skin's hydration

Patient with oily acne skin

EXPERIMENTAL

Other: Collects of skin's hydration

Control group of patient without facial dermatosis

ACTIVE COMPARATOR

Other: Collects of skin's hydration

Interventions

Collects of skin's hydration OTHER

Collects of skin's hydration will be made by using patch using electrochemistry.

Atopic dermatitis patients; Control group of patient without facial dermatosis; Patient with oily acne skin

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ≤ Age ≤ 70
• Subjects with past history or follow-up for acne or rosacea stage I ou II, atopic dermatitis mild to moderate without immunosuppressive treatment
• Subjects enabling to perform a one day visit at the hospital
• Written consent according to local regulatory requirements
• Affiliated to a social security scheme

You may not qualify if:

• Pregnant women or breastfeeding
• Patient under guardianship or curatorship, legal protection or protection of justice
• Participation in other interventional research on skin moisturizer

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• SYNELVIA: collaborator
• WIRED BEAUTY Technologies: collaborator

Study Sites (1)

Assistance Publique Hôpitaux de Paris - CHU Henri Mondor

Créteil, 94040 Créteil Cedex, France

Location

MeSH Terms

Conditions

Dermatitis, Atopic; Acne Vulgaris

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Acneiform Eruptions; Sebaceous Gland Diseases

Study Officials

• Tu Anh Duong, MD PhD

  Assistance Publique - Hôpitaux de Paris

  STUDY DIRECTOR

Central Study Contacts

Tu Anh Duong, MD PhD

CONTACT

01 49 09 44 29; tu-anh.duong@aphp.fr

David Schmitz

CONTACT

01 49 81 36 32; david.schmitz@aphp.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This study will include sixty subjects separate into three groups of twenty subjects based on the skin disease: acne, atopic dermatitis and a group control. This is a study validating the feasibility of a measure collected by a tool at the prototype stage with a view to pre-industrialization. The following process is: Measurement by patches and sensors of substances of interest on 2 areas of the face separated by the midline (forehead / cheek). Collection on the skin surface by 2 swabs repeated on 2 areas

Study Record Dates

• First Submitted: September 9, 2021
• First Posted: October 8, 2021
• Study Start: October 15, 2021
• Primary Completion: December 16, 2021
• Study Completion: December 16, 2021
• Last Updated: October 18, 2021

Record last verified: 2021-09

Locations

FR (1)