Severity of RSV Infections in Twins

NCT05070975 | Completed

• 1 other identifier: 69HCL21_0634
• Study Type: observational
• Target: 94
• Locations: 1 country
• Sites: 1

Brief Summary

Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide. Age at the time of infection, prematurity, multiparity, exposure to smoke and the level of passive immunity transmitted at birth are the main risk factors for lower respiratory infection associated with RSV. Other factors, including the innate immune response, respiratory microbiota, and intra-host viral heterogeneity, may also affect outcomes but are not fully considered in RSV infection. Exploring the impact of these factors is difficult due to the heterogeneity of the population which makes statistical adjustment difficult. Thus, twin models are useful in understanding the impact of the host on the environment, as twins often share similar exposure to infection and many risk factors, but not all are ie different prenatal and postnatal conditions, differential transfer of maternal antibodies and the genetic makeup of heterozygotes.

Conditions

RSV Infection; Bronchiolitis

Keywords

RSV infections in twins; Bronchiolitis; very-severe-LRTI; severe-LRTI; LRTI; upper respiratory tract infection; RSV infection; Human; infant

Outcome Measures

Primary Outcomes (1)

• Percentage of discordant twin pairs in severity of Respiratory Syncytial Virus infections.

  The primary outcome measure is the percentage of discordant twin pairs of at least one severity level on the WHO (World Health Organization) scale. The discrepancy in the level of severity is obtained by retrospective analysis of the data from the medical file.

  1 day

Study Arms (1)

Twins

Twins identified from the birth cohort (Hospices Civils de Lyon) with at least one twin hospitalized for an acute RSV-infection

Other: Epidemiology

Interventions

Epidemiology OTHER

Assessment of the discrepancy of clinical severity of RSV-infections between twin infants.

Twins

Eligibility Criteria

• Age: Up to 354 Days
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Twins identified from the birth cohort (Hospices Civils de Lyon) with at least one twin hospitalized for an acute RSV-infection

You may qualify if:

• Twins born at Hospices Civils de Lyon in the years 2012 to 2020
• At least one twin hospitalized with positive RSV-PCR during the first year of life

You may not qualify if:

• Major differential underlying disease between twins
• Death of a twin before the RSV epidemic period of the first year of life
• Nosocomial infection
• Lack of understanding of the study or questionnaire by parents
• Lack of parental consent

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hôpital Femme-Mère-Enfant des Hospices Civils de Lyon

Bron, 69677, France

Location

MeSH Terms

Conditions

Respiratory Syncytial Virus Infections; Bronchiolitis; Respiratory Tract Infections

Condition Hierarchy (Ancestors)

Pneumovirus Infections; Paramyxoviridae Infections; Mononegavirales Infections; RNA Virus Infections; Virus Diseases; Infections; Bronchitis; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 27, 2021
• First Posted: October 7, 2021
• Study Start: November 5, 2021
• Primary Completion: January 27, 2022
• Study Completion: January 27, 2022
• Last Updated: July 6, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)