NCT05068882

Brief Summary

Patients after the surgical removal of axillary lymphnodes suffers from prolonged fluid collections. The aim of the study is to assess the impact of oral immunonutrition and high-protein diets on the reduction of fluid collection.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Typical duration for not_applicable

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2021

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 25, 2021

Completed
11 days until next milestone

First Posted

Study publicly available on registry

October 6, 2021

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2023

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2023

Completed
Last Updated

October 13, 2021

Status Verified

October 1, 2021

Enrollment Period

1.7 years

First QC Date

September 25, 2021

Last Update Submit

October 5, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Fluid collection

    The volume of fluid collection after lymph nodes resection expressed in mililiters

    6 months

Study Arms (4)

Immunonutrition

EXPERIMENTAL

Oral immunonutrition containing arginine, omega-PUFAs and antioxidants

Dietary Supplement: Immunonutrition

High-protein diet

ACTIVE COMPARATOR

Oral nutrition with high-protein content

Dietary Supplement: High-protein nutrition

Standard nutrition

ACTIVE COMPARATOR

Oral nutrition with standard ingredients

Dietary Supplement: Standard nutrition

No intervention

NO INTERVENTION

No intervention

Interventions

ImmunonutritionDIETARY_SUPPLEMENT

Oral immunonutrition containing arginine, omega-PUFAs and antioxidants

Immunonutrition
High-protein nutritionDIETARY_SUPPLEMENT

Oral nutrition with high-protein content

High-protein diet
Standard nutritionDIETARY_SUPPLEMENT

Oral nutrition with standard ingredients

Standard nutrition

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • confirmed breast cancer or melanoma
  • scheduled surgery with axillary lymph nodes resection
  • informed consent
  • eligible for surgery

You may not qualify if:

  • benign disease
  • no consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Maria Sklodowska-Curie National Cancer Institute

Krakow, Malopolska, 31-115, Poland

RECRUITING

Stanley Dudrick's Memorial Hospital

Skawina, 32-050, Poland

RECRUITING

MeSH Terms

Conditions

Postoperative Complications

Interventions

Immunonutrition Diet

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

DietNutritional Physiological PhenomenaDiet, Food, and NutritionPhysiological Phenomena

Study Officials

  • Stanislaw Klek, PhD

    Stanley Dudrick's Memorial Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Stanislaw Klek, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
The physician is unaware of the type of the intervention. The type of intervention is given by the independent person to dietitian instructing the patient how to use the product.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: 4 arm randomized study
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of the Unit

Study Record Dates

First Submitted

September 25, 2021

First Posted

October 6, 2021

Study Start

June 1, 2021

Primary Completion

January 31, 2023

Study Completion

March 31, 2023

Last Updated

October 13, 2021

Record last verified: 2021-10

Data Sharing

IPD Sharing
Will not share

Locations