Post-COVID-19 Pneumo-hematocele

NCT05067881 | Completed

• 1 other identifier: HGAM02
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

Introduction. As the COVID-19 pandemic has continued, an increasing number of long-term complications are emerging. Recently, the appearance of characteristic pulmonary lesions has been noted, being described as post COVID-19 pneumatocele. The aim of this study is to describe the clinical, histopathologic and imaging features of post COVID-19 pneumo-hematoceles (PHC) and secondarily to suggest a treatment algorithm in these patients. Methods. A retrospective study was performed in patients admitted with diagnosis of SARS-CoV2 infection from March 2020 to September 2021 who presented PHC on imaging studies. Clinical and demographic variables were recorded and CT scans were analyzed. A logistic regression analysis was performed to determine the risk for rupture according to PHC characteristics. It appears that PHC occurs secondary to encapsulation of blood accumulation, the result of micro capillary bleeding, with partial reabsorption of blood and subsequent air filling. The recommendation is to operate on patients with PHC of 5cm and those with persistent lesions of 3cm.

Conditions

COVID-19 Respiratory Infection

Keywords

COVID-19; Pneumohematocele; Giant bullae; Pneumatocele

Outcome Measures

Primary Outcomes (1)

• PHC diagnosis

  Pneumohematoceles on imaging studies

  From date of diagnosis until 4 weeks after diagnosis

Study Arms (1)

Pneumohematocele

Patients with SARS CoV-2 diagnosis and PHC on imaging studies

Procedure: Pulmonary resection

Interventions

Pulmonary resection PROCEDURE

Resection of pneumohematocele

Pneumohematocele

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with a positive chain reaction for SARS CoV-2 who had PHC on imaging studies in two hospitals of Mexico City

You may qualify if:

• Adults with a positive protein chain reaction for SARS-CoV2,
• PHC on imaging studies.

You may not qualify if:

• loss of follow up
• age out of range.

Sponsors & Collaborators

• Hospital General Ajusco Medio: lead
• Instituto Nacional de Enfermedades Respiratorias: collaborator

Study Sites (1)

Karla Verónica Chávez Tostado

Mexico City, 14500, Mexico

Location

Related Publications (26)

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  PMID: 35041128 DERIVED

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Karla V Chavez Tostado, MD

  Head of surgery department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Surgery department

Study Record Dates

• First Submitted: September 28, 2021
• First Posted: October 5, 2021
• Study Start: March 1, 2020
• Primary Completion: March 1, 2020
• Study Completion: September 20, 2021
• Last Updated: October 5, 2021

Record last verified: 2021-10

Locations

ME (1)